81282-13-5

Usage

Uses

Used in Pharmaceutical Synthesis:
(5-(4-Chlorophenyl)isoxazol-3-yl)methanol is used as an intermediate for the synthesis of pharmaceuticals. Its unique structure, including the phenyl ring, chlorine substituent, and isoxazol ring, allows it to be a key component in the development of new medications with potential therapeutic benefits.
Used in Organic Compounds Synthesis:
In addition to its pharmaceutical applications, (5-(4-Chlorophenyl)isoxazol-3-yl)methanol is also used as an intermediate for the synthesis of other organic compounds. Its functional groups make it a valuable building block for creating a wide range of products with various applications in different industries.
Used in Chemical Research:
(5-(4-Chlorophenyl)isoxazol-3-yl)methanol's structural features also make it a useful compound for chemical research. Scientists and researchers can utilize (5-(4-CHLOROPHENYL)ISOXAZOL-3-YL)METHANOL to study its properties, reactivity, and potential interactions with other molecules, leading to a better understanding of its applications and possibilities in various fields.

Upstream product

• 5814-38-0 ethyl 4-chlorobenzoylpyruvate 
• 99-91-2 para-chloroacetophenone 
• 81282-12-4 ethyl 5-(4-chlorophenyl)isoxazole-3-carboxylate 
• 176593-36-5 methyl 5-(4-chlorophenyl)isoxazole-3-carboxylate 
• 39757-35-2 methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate 
• 81282-14-6 5-(p-chlorophenyl)-3-(2-tetrahydropyranyloxymethyl)isoxazole 

Downstream Products

• 109544-05-0 2-[[5-(4-chlorophenyl)-3-isoxazolyl]methoxy]-2-methylpropionic acid 
• 763109-09-7 5-(4-chlorophenyl)isoxazole-3-carboxyaldehyde 
• 1277240-15-9 C₂₅H₂₈ClN₃O₃ 
• 1277100-07-8 C₂₂H₂₂ClN₃O₃*ClH 
• 1277100-12-5 C₂₅H₂₈ClN₃O₃*ClH 
• 1277100-15-8 C₂₃H₂₄ClN₅O₃*ClH 
• 1277100-21-6 2-{[5-(4-chlorophenyl)isoxazol-3-yl]methoxy}aniline 
• 1277100-23-8 N-(2-{[5-(4-chlorophenyl)isoxazol-3-yl]methoxy}phenyl)piperidine-4-carboxamide hydrochloride 
• 1277100-25-0 C₂₅H₂₈ClN₃O₃*ClH 
• 1277100-27-2 C₂₃H₂₄ClN₅O₃*ClH 
• 1277240-06-8 C₂₅H₂₈ClN₃O₃ 
• 1277100-19-2 5-(4-chlorophenyl)-3-[(2-nitrophenoxy)methyl]isoxazole 

Relevant academic research and scientific papers

Novel N-Substituted oseltamivir derivatives as potent influenza neuraminidase inhibitors: Design, synthesis, biological evaluation, ADME prediction and molecular docking studies

The discovery of novel potent neuraminidase (NA) inhibitors remains an attractive approach for treating infectious diseases caused by influenza. In this study, we describe the design and synthesis of novel N-substituted oseltamivir derivatives for probing the 150-cavity which is nascent to the activity site of NA. NA inhibitory studies showed that new derivatives demonstrated the inhibitory activity with IC50 values at nM level against NA of a clinical influenza virus strain. Moreover, the in silico ADME predictions showed that the selected compounds had comparable properties with oseltamivir carboxylate, which demonstrated the druggablity of these derivatives. Furthermore, molecular docking studies showed that the most potent compound 6f and 10i could adopt different modes of binding interaction with NA, which may provide novel solutions for treating oseltamivir-resistant influenza. Based on the research results, we consider that compounds 6f and 10i have the potential for further studies as novel antiviral agents.

Design, synthesis and structure-based optimization of novel isoxazole-containing benzamide derivatives as FtsZ modulators

Antibiotic resistance among clinically significant bacterial pathogens is becoming a prevalent threat to public health, and new antibacterial agents with novel mechanisms of action hence are in an urgent need. Utilizing computational docking method and structure-based optimization strategy, we rationally designed and synthesized two series of isoxazol-3-yl- and isoxazol-5-yl-containing benzamide derivatives that targeted the bacterial cell division protein FtsZ. Evaluation of their activity against a panel of Gram-positive and -negative pathogens revealed that compounds B14 and B16 that possessed the isoxazol-5-yl group showed strong antibacterial activity against various testing strains, including methicillin-resistant Staphylococcus aureus and penicillin-resistant S. aureus. Further molecular biological studies and docking analyses proved that the compound functioned as an effective inhibitor to alter the dynamics of FtsZ self-polymerization via a stimulatory mechanism, which finally terminated the cell division and caused cell death. Taken together, these results could suggest a promising chemotype for development of new FtsZ-targeting bactericidal agent.

Design, synthesis and bioactivities of novel isoxazole-containing pyrazole oxime derivatives

In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against Tetranychus cinnabarinus, Aphis medicaginis, Mythimna separata, and Nilaparvata lugens. Especially, compounds 9c, 9h, 9u, and 9v showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against A. medicaginis at the concentration of 20 μg/mL, respectively, compounds 9k and 9u had 70.86% and 100.00% insecticidal activities against M. separata at 20 μg/mL, respectively.

2-Amino-3-cyano-4-(5-arylisoxazol-3-yl)-4H-chromenes: Synthesis and in vitro cytotoxic activity

A new series of 4-aryl-4H-chromenes bearing a 5-arylisoxazol-3-yl moiety at the C-4 position were prepared as potential anticancer agents. The in vitro cytotoxic activity of the synthesized compounds was investigated against a panel of tumor cell lines in

Biarylmethoxy isonipecotanilides as potent and selective inhibitors of blood coagulation factor Xa

New chloro-substituted biarylmethoxyphenyl piperidine-4-carboxamides were synthesized and assayed in vitro as inhibitors of the blood coagulation enzymes factor Xa (fXa) and thrombin. An investigation of effects of the amidine and isopropyl groups attache

Processes For The Preparation Of Anti-Viral Compounds And Compositions Containing Them

Disclosed are processes for the preparation of compounds of formula I and compositions that comprise said compounds of formula I. Also disclosed are processes for the preparation of compounds of formula III and compositions that comprise said compounds of formula III.

ANTI-VIRAL COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

Disclosed are compounds of Formula (I), pharmaceutically acceptable salts and solvates thereof, compositions thereof, and methods for their preparation and uses for treating viral infections mediated at least in part by a virus in the Flaviviridae family of viruses. (I)