81282-91-9

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 81282-95-3 4-[(E)-2-(3-Methyl-4-nitro-isoxazol-5-yl)-vinyl]-phenol 
• 123-54-6 acetylacetone 

Downstream Products

• 78636-41-6 4-[1-(3,5-Dimethyl-isoxazol-4-yl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-phenol 
• 98239-39-5 4-[1-(3,5-Dimethyl-1H-pyrazol-4-yl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-phenol 
• 98239-50-0 4-[1-(3,5-Dimethyl-1-phenyl-1H-pyrazol-4-yl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethyl]-phenol 

Relevant academic research and scientific papers

Chemistry of Heterocylces: Part VIII - Synthesis of Isoxazolylethylpyrazoles

The base-catalysed addition of acetylacetone to 3-methyl-4-nitro-5-styrylisoxazoles (II) leads to the Michael adducts 3-pentane-2,4-diones (III).These β-diketones (III) undergo cyclization with hydrazine sulphate and phenylhydrazine to furnish pyrazoles (IV) and N-phenylpyrazoles (V), respectively.

Ethylene-diheterocycles: Part I - Synthesis of 5--3-methyl-4-nitroisoxazoles

Michael addition of acetylacetone to 3-methyl-4-nitro-5-styrylisoxazoles (I) in triethylamine leads to 3--2,4-pentanediones (II).The pentanediones (II) undergo cyclisation with hydroxylamine to give 5-ω