81289-20-5Relevant academic research and scientific papers
Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis
Vroemans, Robby,Verhaegen, Yenthel,Dieu, My Tran Thi,Dehaen, Wim
, p. 2689 - 2697 (2018)
A new metal-free one-pot three-component procedure towards fully substituted triazolochromenes has been developed, starting from commercially available materials. Salicylaldehydes and nitroalkenes were reacted under solvent-free conditions, followed by a
Mild and efficient reductive deoxygenation of epoxides to olefins with tin(II) chloride/sodium iodide as a novel reagent
Pathe, Gulab Khushalrao,Ahmed, Naseem
supporting information, p. 3542 - 3552 (2015/11/17)
A highly efficient and green protocol is reported for the reductive deoxygenation of organic epoxides to olefins using tin(II) chloride/sodium iodide as a novel reagent. The reaction gives an excellent yield (85-96%) in ethanol under reflux within 2-10 minutes, without affecting other functional groups. The advantages of our method are the use of inexpensive reagents, the eco-friendly and green reaction conditions, and the short reaction times and high yields.
Synthesis, in vitro cytotoxicity and apoptosis inducing study of 2-aryl-3-nitro-2 H -chromene derivatives as potent anti-breast cancer agents
Rahmani-Nezhad, Samira,Safavi, Maliheh,Pordeli, Mahboobeh,Ardestani, Sussan Kabudanian,Khosravani, Leila,Pourshojaei, Yaghoub,Mahdavi, Mohammad,Emami, Saeed,Foroumadi, Alireza,Shafiee, Abbas
, p. 562 - 569 (2015/01/09)
A series of 2-aryl-3-nitro-2H-chromenes 4a-u were designed as hybrid analogs of flavanone, β-nitrostyrene and nitrovinylstilbene scaffolds. They were synthesized from the reaction of appropriate β-nitrostyrenes and salicylaldehydes in good yields. In vitro cytotoxic activities of compounds 4a-u were tested against breast cancer cell lines including MCF-7, T-47D and MDA-MB-231. Most compounds exhibited good cytotoxic activity against selected cell lines, being more potent than standard drug etoposide. Representatively, 8-methoxy-3-nitro-2-(4-chlorophenyl)-2H-chromene (4l) with IC50 Combining double low line 0.2 μ4M against MCF-7 cells, was 36-times more potent than etoposide. Apoptosis as a mechanism of cell death for selected compounds 4h and 4l was confirmed morphologically by acridine orange/ethidium bromide double staining and TUNEL analysis, as well as caspase-3 activation assay.
Sodium Borohydride Reduction of 3-Nitro-2-substituted-phenyl-2H-benzopyrans
Arora, P. K.,Bhaduri, A. P.
, p. 951 - 954 (2007/10/02)
Reaction of 3-nitro-2-substituted-phenyl-2H-benzopyrans (1-8) with NaBH4 at 5-10 deg C followed by reduction of the nitro group with hydrazine hydrate in the presence of Raney-nickel furnishes 3-amino-2-substituted-phenyl-3,4-dihydro-2H-benzopyrans
