81305-69-3

Upstream product

• 110-94-1 1,5-pentanedioic acid 
• 106-49-0 p-toluidine 
• 1121-89-7 piperidine-2,6-dione 
• 108-55-4 glutaric anhydride, 
• 71195-71-6 N-Tolyl-glutaramidsaeure 

Downstream Products

• 106-49-0 p-toluidine 
• 81305-74-0 2,6-Dichlor-3,5-diformyl-1,4-dihydro-1-tolyl-pyridin 
• 103827-12-9 N-(5-{[2-(4-imidazolyl)ethyl]amino}glutaryl)-p-toluidine 

Relevant academic research and scientific papers

Unlocking Amides through Selective C–N Bond Cleavage: Allyl Bromide-Mediated Divergent Synthesis of Nitrogen-Containing Functional Groups

We report a new set of reactions based on the unlocking of amides through simple treatment with allyl bromide, creating a common platform for accessing a diverse range of nitrogen-containing functional groups such as primary amides, sulfonamides, primary amines, N-acyl compounds (esters, thioesters, amides), and N-sulfonyl esters. The method has potential industrial applicability, as demonstrated through gram-scale syntheses in batch and in a continuous flow system.

Synthesis of some biologically active 2,6-dichloro-1-(N-substituted phenyl)-1,4-dihydropyridine-3,5-Dicarbaldehydes using vilsmeier-haack reaction and their applications

Various 2,6-dichloro-1-(N-substituted phenyl)-1,4-dihydropyridine-3,5- dicarbaldehydes were synthesized in two steps using moderate conditions and 3,5-diformyl groups were transformed into different functionalities. The synthesized compounds were screened

N -alkynyl imides (ynimides): Synthesis and use as a variant of highly labile ethynamine

This study describes the first reliable synthesis of N-alkynyl imides (ynimides). This was accomplished with a copper-catalyzed coupling reaction between alkynyl(triaryl)bismuthonium salts and five-membered imides. We also found that it was possible to utilize N-ethynyl phthalimide as a variant of the highly labile ethynamine. 4-Amino-1,2,3-triazole was successfully obtained via the CuAAC reaction of N-ethynyl phthalimide with azide followed by hydrazinolysis of the phthaloyl protecting group.

Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides

This study describes the antinociceptive activity of some N-aryl-glutaramic acids and N-aryl-glutarimides in writhing and formalin tests, two classical models of pain in mice. These compounds show high activity, being more active than acetyl salycilic aci

The Function of Sodium Acetate in Cyclodehydration of Glutaranilic Acids

The rate of cyclodehydration of glutaranilic acids in acetic anhydride in the presence of sodium acetate affording N-arylglutarimides was studied. The reaction was established to proceed irreversible with quantitative yield in keeping with fitst order kin

Congener derivatives and conjugates of histamine: Synthesis and tissue and receptor selectivity of the derivatives

A series of 19 congener derivatives and conjugates of histamine was synthesized and tested to determine whether the ligands would alter the conventional histamine activity in various tissues. The derivatives, which contained either branched or unbranched