81324-30-3

Upstream product

• 69739-34-0 t-butyldimethylsiyl triflate 
• 76517-80-1 diphenylmethyl 6β-(hydroxymethyl)penicillanate 

Downstream Products

• 229489-96-7 (2S,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3,3-dimethyl-4,7-dioxo-4λ⁴-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229490-05-5 (2S,3S,5R,6R)-3-((Z)-2-Cyano-vinyl)-6-hydroxymethyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229490-06-6 (2S,3S,5R,6R)-3-((E)-2-Cyano-vinyl)-6-hydroxymethyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229490-01-1 (2S,3R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-formyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229490-00-0 (2S,3R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxymethyl-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229490-09-9 (2S,3R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(methoxyimino-methyl)-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229490-02-2 (2S,3S,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-((Z)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229490-04-4 (2S,3S,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-((E)-2-cyano-vinyl)-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229489-98-9 (2S,3R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(2-chloro-acetoxymethyl)-3-methyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 
• 229489-99-0 (2S,3R,5R,6R)-6-(tert-Butyl-dimethyl-silanyloxymethyl)-3-(2-chloro-acetoxymethyl)-3-methyl-4,4,7-trioxo-4λ⁶-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester 

Relevant academic research and scientific papers

Stereoselective reduction of α-bromopenicillanates by tributylphosphine

Diastereoselective reduction of 6-bromo-6-substituted penicillanate esters has been achieved by treatment with tributylphosphine to give 6-substituted penicillanate esters. This reaction would appear to proceed through a phosphonium β-lactam enolate speci

6-(1-Hydroxyalkyl)penam sulfone derivatives as inhibitors of class A and class C β-lactamases II

Two stereoselective processes for the synthesis of novel 3,6- disubstituted penam sulfone derivatives were developed. One 6β-(1- hydroxyethyl) and four 6β-hydroxymethyl penam sulfone derivatives were synthesized. All four 6β-(hydroxymethyl)penam sulfone d