81326-17-2Relevant academic research and scientific papers
Enzymatic Hydrolysis of Heterocyclic Nitriles
Klempier, Norbert,Raadt, Anna de,Griengl, Herfried,Heinisch, Gottfried
, p. 93 - 95 (2007/10/02)
Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp.Pyrimidine-2-carbonitrile (2a) and 3-chloropyridazine-4-carbonitrile (4a) were converted into the corresponding amides while from 2-ethoxycarbonyl-4-pyridinecarbonitrile (1a), 6-methylpyridazine-3-carbonitrile (3a), 3-chloropyridazine-4-carbonitrile (4a), 3-ethoxycarbonyl-4,5-dihydroisoxazole-5-carbonitrile (8a), indole-3-carbonitrile (9a), and indole-3-ylacetonitrile (10a) the acids were formed.
