813445-29-3

Upstream product

• 813445-28-2 {(1R,2S,4R)-2-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-4-methylamino-cyclohexyl}-carbamic acid benzyl ester 
• 108-24-7 acetic anhydride 

Downstream Products

• 813445-30-6 N-{(1R,3S,4R)-4-amino-3-[(S)-3-(4-fluorobenzyl)-piperidin-1-ylmethyl]-cyclohexyl}-N-methyl-acetamide 

Relevant academic research and scientific papers

Process of preparing N-ureidoalkyl-piperidines

The present application describes a process of preparing a compound of formula (IV), or salt or stereoisomer thereof: wherein Pg, at each occurrence, is independently selected from an amine protecting group; comprising the steps of reacting a compound of Formula with a reducing agent to give a compound of Formula III: reacting the compound of formula (III) with an amine of formula (IIa) using reductive amination to give the compound of formula (III)

N-ureidoalkyl-piperidines as modulators of chemokine receptor activity

The present application describes modulators of chemokine receptor activity of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases, as well as autoimmune pathologies such as rheum