813449-45-5Relevant academic research and scientific papers
Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry
Barnes, Matthew J.,Conroy, Richard,Miller, David J.,Mills, John S.,Montana, John G.,Pooni, Parminder K.,Showell, Graham A.,Walsh, Louise M.,Warneck, Julie B.H.
, p. 354 - 357 (2007)
The synthesis, physicochemical properties and pharmacological profiles of two novel silicon-containing p38 MAP kinase inhibitors are described.
SILYLATED HETEROCYCLYLUREA DERIVATIVES AS CYTOKINE-INHIBITORS
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Page/Page column 31, (2010/02/10)
A compound of formula (I) Wherein R1, R2 and R3 are the same or different and are each alkyl, -aikyl-aryl or -alkyl-cycloalkyl; or R1-Si-R2 taken together form heterocycloalkyl; R4 is aryl
