81358-09-0Relevant articles and documents
Addition of Trimethylsilyl Enol Ethers to Isoquinolinium Salts: A Facile Synthesis of 1-(2-Oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)- 1,2-dihydroisoquinolines and Their Cyclization for the Synthesis of the Isoquinoline Alkaloid Skeleton
Akiba, Kin-ya,Nakatani, Masayuki,Wada, Makoto,Yamamoto, Yohsuke
, p. 63 - 68 (1985)
The addition of trimethylsilyl enol ethers to 2-acylisoquinolinium salts afforded 1-(2-oxoalkyl)-2-(ethoxycarbonyl)(or acetyl)-1,2-dihydroisoquinolines (3) in excellent yields.These compounds were cyclized with bases to give benzoquinolizine derivative
ADDITION OF BORON ENOLATES TO ISOQUINOLINIUM SALTS : A FACILE SYNTHESIS OF 1-β-KETO SUBSTITUTED 2-ETHOXYCARBONYL-1,2-DIHYDROISOQUINOLINES AND THEIR CYCLIZATION
Akiba, Kin-ya,Araki, Kei-ichi,Nakatani, Masayuki,Wada, Makoto
, p. 4961 - 4964 (2007/10/02)
An efficient method to synthesize 1-β-keto substituted 2-ethoxycarbonyl (or 2-acetyl)-1,2-dihydroisoquinolines (3) is described, utilizing boron enolates and isoquinolinium salts.The products were treated with sodium ethoxide to afford the corresponding c