81377-02-8

Basic information

• Product Name: SEGLITIDE
• Synonyms: SEGLITIDE;MK 678;CYCLIC(N-METHYL-ALA-TYR-D-TRP-LYS-VAL-PHE);Cyclic(N-methyl-Ala-Tyr-D-Trp-Lys-Val-Phe), MK 678;M.W. 808.98 C44H56N8O7;Cyclo(L-Tyr-D-Trp-L-Lys-L-Val-L-Phe-N-methyl-L-Ala-);L-363586;N-Methyl-cyclo(L-Ala-L-Tyr-D-Trp-L-Lys-L-Val-L-Phe-)
• CAS NO: 81377-02-8
• Molecular Formula: C₄₄H₅₆N₈O₇
• Molecular Weight: 808.96
• Product Categories: Somatostatin receptor
• Mol File: 81377-02-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 1194.3±65.0 °C(Predicted)
• Appearance: white/solid
• Density: 1.186±0.06 g/cm3(Predicted)
• Refractive Index: 1.569
• Storage Temp.: 2-8°C
• Solubility: H2O: 26 mg/mL, soluble
• PKA: pKa 9.7(H2O) (Uncertain)
• CAS DataBase Reference: SEGLITIDE(CAS DataBase Reference)
• NIST Chemistry Reference: SEGLITIDE(81377-02-8)
• EPA Substance Registry System: SEGLITIDE(81377-02-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 81377-02-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 81377-02-8 differently. You can refer to the following data:
1. Antidiabetic.
2. Seglitide is a somatostatin (SST) agonist.

InChI:InChI=1/C44H56N8O7/c1-26(2)38-43(58)50-37(23-28-12-6-5-7-13-28)44(59)52(4)27(3)39(54)48-35(22-29-17-19-31(53)20-18-29)41(56)49-36(24-30-25-46-33-15-9-8-14-32(30)33)42(57)47-34(40(55)51-38)16-10-11-21-45/h5-9,12-15,17-20,25-27,34-38,46,53H,10-11,16,21-24,45H2,1-4H3,(H,47,57)(H,48,54)(H,49,56)(H,50,58)(H,51,55)/t27-,34-,35-,36+,37-,38-/m0/s1

Upstream product

• 86048-89-7 D-Trp-Lys(Cbz)-Val-Phe-N-Me-Ala-Tyr-OH 
• 86029-13-2 Boc-D-Trp-Lys(Cbz)-Val-Phe-N-Me-Ala-Tyr-OH 
• 86029-12-1 Boc-D-Trp-Lys(Cbz)-Val-Phe-N-Me-Ala-Tyr-OMe 
• 86066-92-4 cyclo-(D-Trp-Lys(Cbz)-Val-Phe-N-Me-Ala-Tyr-) 
• 68802-79-9 Boc-D-Trp-Lys(Cbz)-OMe 
• 86029-11-0 Boc-D-Trp-Lys(Cbz)-OH 
• 127476-51-1 C₂₁H₂₈N₂O₆ 
• 5241-64-5 Boc-D-Trp-OH 
• 73548-77-3 Boc-L-Lys(Z)-OMe 
• 112883-29-1 N-Fmoc-Tyr-OH 
• 84000-07-7 N-(9-fluorenylmethoxycarbonyl)-N-methyl-L-alanine 
• 105047-45-8 Fmoc-Lys-OH 
• 35737-15-6 N-(9-fluorenylmethoxycarbonyl)-D-tryptophan 

Relevant articles and documents

Solid phase synthesis of 'head-to-tail' cyclic peptides using a sulfonamide 'safety-catch' linker: The cleavage by cyclization approach

A new approach to the synthesis of cyclic peptides using Kenner's 'safety-catch' sulfonamide linker is described. After the linear peptide is assembled by Fmoc peptide synthesis, trityl is adopted as a temporary protecting group for the N-terminus amine while activating the acyl sulfonamide linker. Head-to-tail cyclization-cleavage of the amine to the acyl sulfonamide ensured final product purity.