81380-04-3

Upstream product

• 5064-52-8 2-methyl-4-tert-butylcyclohexanone 
• 81380-02-1 4α-tert-butyl-2β-(2'-cyanoethyl)-2α-methylcyclohexanone 
• 81380-01-0 1-(trimethylsiloxy)-2-methyl-4-tert-butyl-1-cyclohexene 
• 81380-05-4 6α-tert-butyl-10α-methyl-1-oxa-9α-decal-2-one 
• 81380-03-2 3-(5'-tert-butyl-1'methyl-2'-oxacyclohexyl) propionic acid 

Relevant academic research and scientific papers

Stereochemical studies. X. Synthesis of some epimeric δ-lactones

Stereospecific synthesis are reported for the δ-lactones 3, 5, 8, 17, and 26.

Stereochemical studies. XI. Equilibria between δ-hydroxy-acids and δ-lactones in aqueous tetrahydrofuran. Relative stabilities of isomeric δ-lactones

The equilibrium constants K' for the hydrolysis of 13 δ-lactones to hydroxy-acids in 54percent (mol/mol) aqueous tetrahydrofuran at 25 deg C have been determined.The equilibrium constants for the isomerization of the five δ-lactones into their epimers, and for the isomerization of their hydroxy-acids into their epimers, have been calculated by the methods of conformational analysis.These calculated values are consistent with the experimental values of K'.Addition of methyl groups to a hydroxy-acid decreases K' (the Thorpe-Ingold effect).