81382-51-6Relevant articles and documents
Imidazole systems. I. Imidazo[2,1 b][1,3,5]benzothiadiazepine derivatives as potential antipsychotic agents
Della Vecchia,Dellureficio,Kisis,Vlattas
, p. 1287 - 1294 (2007/10/02)
Imidazo[2,1-b][1,3,5]benzothiadiazepine 3 constitutes a novel ring system, and its analogs 3a-i were synthesized to investigate their potential antipsychotic activity. The synthesis of the ring system was achieved by reaction of 2-aminophenylthioimidazoles 7 with phosgene or thiophosgene and by ring closure of the 1-[2-(2-imidazolyl)thiophenyliminocarbonyl]-1 piperazines 13. An efficient method for the conversion of thioureas 8, 12 to guanidine 3a via the corresponding cyanothioamidines 11, 14 was developed.