81400-35-3Relevant academic research and scientific papers
Syntheses of New N-Vinylpyrroles
Neidlein, Richard,Jeromin, Guenter
, p. 714 - 721 (2007/10/02)
The reactions of pyrrolyl potassium (1) with (ethoxymethylene)malonic acid derivatives 2a - e yielded the carbanions 3a - e, which could be hydrolyzed to 4a - e, but with the exception of 4b they were not isolated, because a transformation to the N-vinylpyrroles 5a, c - e by elimination of ethanol took place; 1 reacted with 2b at 80 deg C to give 4b and 6.Hydrolysis of 4b with KOH yielded 4g, which eliminated 1 mol of ethanol to form 5f, decarboxylation of which led to N-vinylpyrrole 7.By cyclization of 5e under various conditions the pyrrolizines 8a, b are obtained, the hydrolysis of which did not give ketone 9 but only amino alcohol 10.Some other cyclizations of 11a - c and 13 yielded the 3H-pyrrolizine derivatives 12a - c and 14, respectively.
