81403-67-0

Basic information

• Product Name: Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide
• Synonyms: Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide;2-Furancarboxamide,tetrahydro-N-[3-(methylamino)propyl]-;N-(3-(MethylaMino)propyl)tetrahydrofuran-2-carboxaMide;N-[3-(METHYLAMINO)PROPYL]-2-TETRAHYDROFURAN-CARBOXAMIDE(AF4)
• CAS NO: 81403-67-0
• Molecular Formula: C₉H₁₈N₂O₂
• Molecular Weight: 186.25142
• EINECS: 1806241-263-5
• Product Categories: Drug Intermediates
• Mol File: 81403-67-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 380.81 °C at 760 mmHg
• Flash Point: 184.108 °C
• Appearance: /
• Density: 1.045 g/cm³
• PKA: 14.93±0.20(Predicted)
• CAS DataBase Reference: Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide(CAS DataBase Reference)
• NIST Chemistry Reference: Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide(81403-67-0)
• EPA Substance Registry System: Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide(81403-67-0)

Safety Data

• Hazardous Substances Data: 81403-67-0(Hazardous Substances Data)

Usage

General Description

Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide is a chemical compound that contains a tetrahydrofuran ring fused to a carboxylic acid group and an amide group. The compound also features a 3-methylamino propyl side chain attached to the amide group. This chemical is commonly used in pharmaceutical research and development, particularly in the synthesis of potential drug candidates. It has shown promise in the treatment of certain medical conditions and is currently being investigated for its potential therapeutic properties. Additionally, Tetrahydrofuran-2-CarboxylicAcid(3-Methylamino-Propyl)-Amide may also have applications in other industries such as chemical manufacturing and material science.

Upstream product

• 52449-98-6 tetrahydrofuran-2-carbonyl chloride 
• 6291-84-5 N-Methyl-1,3-propanediamine 
• 167391-50-6 C₈H₁₂O₅ 
• 16874-33-2 tetrahydro-2-furancarboxylic acid 
• 37443-42-8 methyl tetrahydrofuran-2-carboxylate 
• 72104-44-0 tetrahydro-N-(3-cyanopropyl)-N-methylfurancarboxamide 

Downstream Products

• 81403-80-7 alfuzosin 
• 81403-68-1 alfuzosin hydrochloride 

Relevant articles and documents

Improved method used for preparing quinazoline drugs

The invention relates to an improved method used for preparing quinazoline drugs, and provides a synthesis route taking 2-chloro-4-amino-6,7-dimethoxyquinazoline as an intermediate. The synthesis route comprises following steps: acrylonitrile and a methylamine alcohol solution are subjected to amination reaction so as to obtain intermediate (I); triethylamine is taken as an acid binding agent, andbenzyl chloride is taken as a protective group so as to obtain an intermediate (II); a metal hydride is adopted so as to obtain an intermediate (III) through reduction; acylation with tetrahydro-2-furancarbonylchloride is carried out so as to obtain an intermediate (IV); the intermediate (IV) and ammonium formate are subjected to hydrogenolysis under catalytic effect of palladium on carbon so asto obtain an intermediate (V); and at least condensation reaction with 2-chloro-4-amino-6,7-dimethoxyquinazoline is carried out so as to obtain quinazoline drug Alfuzosin Hydrochloride (VI). Comparedwith the prior art, the improved method possesses following advantages: operation is simple and safe; reaction conditions are convenient to control; energy consumption is low; yield is stable; and industrialized application prospect is promising.

Chemoselective calcium-catalysed direct amidation of carboxylic esters

Unactivated carboxylic esters and primary amines undergo calcium-catalysed direct amide bond formation in excellent yields under homogeneous conditions in toluene. This green and mild reaction proceeds chemoselectively with esters, whereas related carboxylic acids and amides remain unreactive.

AN IMPROVED AND INDUSTRIAL PROCESS FOR THE PREPARATION OF ALFUZOSIN HYDROCHLORIDE AND ITS NOVEL POLYMORPHS

An improved and industrial process for the preparation of Alfuzosin Hydrochloride and its novel polymorphs (Formula (I)).