81411-64-5 Usage
Uses
Used in Cancer Treatment:
1H-Pyrazolo[3,4-b]pyrazin-3-amine is used as an anticancer agent for its potential to inhibit the growth and survival of cancer cells. By blocking the JNK enzyme, it can disrupt the signaling pathways that promote tumor progression, making it a valuable tool in the fight against cancer.
Used in Neurodegenerative Disease Research:
1H-Pyrazolo[3,4-b]pyrazin-3-amine is being researched for its potential applications in treating neurodegenerative diseases. Its ability to modulate the JNK pathway, which is implicated in the pathogenesis of several neurodegenerative conditions, positions it as a candidate for further exploration in this area.
Used in Inflammatory Condition Management:
1H-Pyrazolo[3,4-b]pyrazin-3-amine is also being investigated for its potential in managing inflammatory conditions. Given the role of the JNK enzyme in inflammatory responses, 1H-Pyrazolo[3,4-b]pyrazin-3-amine may offer therapeutic benefits in controlling inflammation-related diseases.
Used in Medicinal Chemistry and Drug Discovery:
Due to its pharmacological properties, 1H-Pyrazolo[3,4-b]pyrazin-3-amine is of significant interest to researchers in the fields of medicinal chemistry and drug discovery. Its unique structure and enzyme inhibitory capabilities make it a valuable compound for the development of new therapeutic agents targeting various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 81411-64-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,4,1 and 1 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 81411-64:
(7*8)+(6*1)+(5*4)+(4*1)+(3*1)+(2*6)+(1*4)=105
105 % 10 = 5
So 81411-64-5 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N5/c6-4-3-5(10-9-4)8-2-1-7-3/h1-2H,(H3,6,8,9,10)
81411-64-5Relevant academic research and scientific papers
PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATMENT, AMELIORATION OR PREVENTION OF INFLUENZA
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Page/Page column 67; 68, (2017/09/02)
Provided herein is a compound of formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, codrug, cocrystal, tautomer, racemate, enantiomer,or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing influenza.
Neighbouring Group Participation in Formation of Condensed Azines. Formation of Pyrazolo(3,4-b)pyrazines, Isoxazolo(4,5-b)pyrazines and Isothiazolo(5,4-b)pyridine (Heterocycles, CCX)
Kocevar, Marjan,Vercek, Bojan,Stanovnik, Branko,Tisler, Miha
, p. 731 - 744 (2007/10/02)
Pyrazine- and pyridinecarboxamidoximes with an amino, potentially tautomeric hydroxy or mercapto group in ortho position could be transformed in the appropriate condensed azines.In this manner, representatives of pyrazolo(3,4-b)pyrazine, isoxazolo(4,5-b)pyrazine and isothiazolo(5,4-b)pyridine ring system were synthesized and some transformations investigated. - Keywords: Cyclization with N-N, N-O or N-S bond formation; Heterocyclic compounds
NEW SYNTHETIC APPROACH FOR PYRAZOLOPYRAZINES AND ISOXAZOLOPYRAZINES
Kocevar, Marjan,Tisler, Miha,Stanovnik, Branko
, p. 339 - 342 (2007/10/02)
A new synthetic approach has been developed for the synthesis of pyrazolepyrazines (7) and isoxazolopyrazines (22) from the corresponding substituted pyrazines.
