81431-45-0

Upstream product

• 17742-50-6 2-(4-bromobenzylthio)acetic acid 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 106-38-7 para-bromotoluene 

Downstream Products

• 300699-55-2 (E)-4-Iodostyryl-4-Bromobenzylsulfone 
• 334969-50-5 (E)-2,4,6-trimethoxystyryl-4-bromobenzylsulfone 
• 334969-26-5 (E)-2-hydroxy-3,5-dinitrostyryl 4-bromobenzyl sulfone 
• 334969-21-0 1-bromo-4-(((E)-perfluorostyrylsulfonyl)methyl)-benzene 
• 31355-14-3 4-Brombenzyl-dijodmethyl-sulfon 

Relevant academic research and scientific papers

Design, synthesis and evaluation of 3-substituted coumarin derivatives as anti-inflammatory agents

Coumarin moiety has garnered momentous attention especially in the design of compounds with significant biological activities. In this work, a series of 3-substituted coumarin derivatives 6a-6l were synthesized and fully characterized. Most of the compoun

Design, synthesis and preliminary biological evaluation of benzylsulfone coumarin derivatives as anti-cancer agents

In this work, a series of benzylsulfone coumarin derivatives 5a-5o were synthesized and characterized. Kinase inhibitory activity assay indicated that most of the compounds showed considerable activity against PI3K. Anti-tumor activity studies of the active compounds were also carried out in vitro on the Hela, HepG2, H1299, HCT-116, and MCF-7 tumor cell lines by MTS assay. The structure-activity relationships (SARs) of these compounds were analyzed in detail. Compound 5h exhibited the most potent activities against the mentioned cell lines with IC50 values ranging from 18.12 to 32.60 μM, followed by 5m with IC50 values of 29.30-42.14 μM. Furthermore, 5h and 5m clearly retarded the migration of Hela cells in vitro. Next, an in silico molecular docking study was conducted to evaluate the binding models of 5h and 5m towards PI3Kαand PI3Kβ. Collectively, the above findings suggested that compounds 5h and 5m might be promising PI3K inhibitors deserving further investigation for cancer treatment.

EFFECT OF MOLECULAR STRUCTURE ON OPTICAL PROPERTIES OF SULFOXIDE SYSTEMS. p-BROMOBENZYLSULFINYLACETIC ACIDS AND SOME OF THEIR DERIVATIVES. PART III

The synthesis and principal properties of p-bromobenzylsulfinylacetic and p-bromobenzylsulfonylacetic acids are described.Racemic sulfoxide was resolved by crystallization of its diastereomeric salts with optically active bases.The relative configuration of the enantiomers were elucidated.Optical rotatory dispersion of the dextrorotatory enantiomers, its ester and amide in the region 340, ΔH) of racemization of laevorotatory p-bromobenzylsulfinylacetic acid were determined by the classical kinetic methods.