Basic information

Product Name: Losulazine
Synonyms: Piperazine, 1-((4-fluorophenyl)sulfonyl)-4-(4-((7-(trifluoromethyl)-4- quinolinyl)amino)benzoyl)-, monohydrochloride;U 54669F
CAS NO:81435-67-8
Molecular Formula: C27H23ClF4N4O3S
Molecular Weight: 595.0081
EINECS: N/A
Product Categories: N/A
Mol File: 81435-67-8.mol

Chemical Properties

Melting Point: N/A
Boiling Point: 695.7°Cat760mmHg
Flash Point: 374.5°C
Appearance: /
Density: g/cm³
Vapor Pressure: 3.35E-19mmHg at 25°C
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: Losulazine(CAS DataBase Reference)
NIST Chemistry Reference: Losulazine(81435-67-8)
EPA Substance Registry System: Losulazine(81435-67-8)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 81435-67-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 81435-67-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,4,3 and 5 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 81435-67:
(7*8)+(6*1)+(5*4)+(4*3)+(3*5)+(2*6)+(1*7)=128
128 % 10 = 8
So 81435-67-8 is a valid CAS Registry Number.

InChI:InChI=1/C27H22F4N4O3S.ClH/c28-20-4-8-22(9-5-20)39(37,38)35-15-13-34(14-16-35)26(36)18-1-6-21(7-2-18)33-24-11-12-32-25-17-19(27(29,30)31)3-10-23(24)25;/h1-12,17H,13-16H2,(H,32,33);1H

81435-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	[4-(4-fluorophenyl)sulfonylpiperazin-1-yl]-[4-[[7-(trifluoromethyl)quinolin-4-yl]amino]phenyl]methanone,hydrochloride

1.2 Other means of identification

Product number	-
Other names	Losulazine monohydrochloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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81435-67-8Related news

Comparison of the Effects of Losulazine (cas 81435-67-8) and Reserpine on Central Aminergic Neurons07/14/2019

The purpose of this study was to examine the effects of both acute and chronic administration of the peripheral sympatholytic antihypertensive agent losulazine on central dopaminergic, noradrenergic, and 5-hydroxytryptaminergic neurons in the rat. For comparison, the acute effects of reserpine w...detailed

Mechanism of anestrus in rats treated with an antihypertensive agent, Losulazine (cas 81435-67-8) hydrochloride07/13/2019

The mechanism of anestrus in rats treated with losulazine, a peripheral sympatholytic antihypertensive agent, was investigated by determining its effect on hypothalamic catecholamines and serum sex hormones and by evaluating the influence of bromocriptine on the reproductive functions of rats tr...detailed

Effects of Losulazine (cas 81435-67-8) on rat reproduction and development07/12/2019

Losulazine, a hypotensive agent, was given orally by gastric intubation to Sprague-Dawley rats in doses of 0, 2, 4, or 8 mg/kg/day in a study of fertility and general reproductive performance. Eighteen males per group were treated for 67 days before cohabitation, then daily until killed. Thirty-...detailed

Study on the activities of testes and accessory sex glands after Losulazine (cas 81435-67-8) treatment in rats07/11/2019

Losulazine hydrochloride, an antihypertensive agent, was administered intraperitoneally to adult male Wistar rats in doses of 1, 2 and 5 mg/kg/day for 1 seminiferous epithelium cycle to determine its effects on testicular steroidogenesis, spermatogenesis and accessory sex gland function. Adminis...detailed

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