81456-46-4 Usage
Uses
Used in Pharmaceutical Industry:
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate 17-valerate is used as a pharmaceutical agent for its anti-inflammatory and immunosuppressive properties. It is particularly effective in treating various inflammatory and autoimmune conditions, such as rheumatoid arthritis, asthma, and allergies, by modulating the immune response and reducing inflammation.
Used in Topical Applications:
In the field of dermatology, 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate 17-valerate is used as a topical treatment for various skin conditions, such as eczema, psoriasis, and dermatitis. Its anti-inflammatory and immunosuppressive properties help alleviate skin inflammation, itching, and redness, providing relief and promoting healing.
Used in Ophthalmic Applications:
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate 17-valerate is also used in ophthalmology as an anti-inflammatory agent for treating eye conditions, such as uveitis and iritis. Its ability to reduce inflammation and suppress the immune response helps manage these conditions and prevent potential vision loss.
Overall, 11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate 17-valerate is a versatile glucocorticoid derivative with a wide range of applications in various industries, particularly in pharmaceuticals, dermatology, and ophthalmology, due to its potent anti-inflammatory and immunosuppressive effects.
Check Digit Verification of cas no
The CAS Registry Mumber 81456-46-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,4,5 and 6 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 81456-46:
(7*8)+(6*1)+(5*4)+(4*5)+(3*6)+(2*4)+(1*6)=134
134 % 10 = 4
So 81456-46-4 is a valid CAS Registry Number.
InChI:InChI=1/C28H40O7/c1-5-6-7-24(33)35-28(23(32)16-34-17(2)29)13-11-21-20-9-8-18-14-19(30)10-12-26(18,3)25(20)22(31)15-27(21,28)4/h14,20-22,25,31H,5-13,15-16H2,1-4H3/t20-,21-,22-,25+,26-,27-,28-/m0/s1
81456-46-4Relevant academic research and scientific papers
Solo,Tramposch,Szeto,Suto
, p. 747 - 749 (1982)
The affinity, relative to cortisol, of 17α- and 21-esters and 17α,21-diesters of cortisol for the glucocorticoid receptor of rat thymus cytosol was determined by a competitive binding assay which used [3H]dexamethasone. Esterification of the 21-hydroxy group of cortisol caused a loss of relative affinity to 0.046 for acetate and 0.32 for valerate. Esterification of the 17α-hydroxy group resulted in an increase in relative affinity to 1.14 for acetate, 12.4 for butyrate, and 11.5 for valerate. Diesters had relative affinities which reflected both trends. Thus, the 21-acetate, 21-propionate, 21-butyrate, and 21-valerate of cortisol 17-acetate had relative affinities of 0.036, 0.093, 0.152, and 0.272. The 21-acetate, 21-propionate, and 21-butyrate of cortisol 17-valerate had relative affinities of 0.76, 1.17, and 1.33.
