81482-09-9Relevant academic research and scientific papers
Alkynylation of steroids via Pd-free Sonogashira coupling
Kotovshchikov, Yury N.,Latyshev, Gennadij V.,Lukashev, Nikolay V.,Beletskaya, Irina P.
, p. 5542 - 5555 (2015)
Cu-catalyzed Pd-free Sonogashira coupling has been proposed as a straightforward and convenient route to valuable steroidal enynes. A biligand catalyst system based on Ph3P and TMEDA has been designed. The protocol was utilized for the efficient coupling of iodosteroids with diverse terminal alkynes and 1-trimethylsilylalkynes. A possible role of an auxiliary ligand as a phase-transfer catalyst for a sparingly soluble inorganic base (K2CO3) was revealed.
Palladium-Catalyzed Reaction of Enol Triflates with 1-Alkynes. A New Route to Conjugated Enynes
Cacchi, Sandro,Morera, Enrico,Ortar, Giorgio
, p. 320 - 322 (2007/10/02)
Cross coupling of enol triflates with 1-alkynes in the presence of a base and bis-palladium(II) diacetate as catalyst at 60 deg C affords conjugated enynes in good yields.The addition of copper(I) iodide as cocatalyst allows the reactions to proceed at room temperature.
Reaction Ways to 3-Acyl-2-Oxo-cholest-5-enes
Berbalk, Hans,Eichinger, Karl,Heisler, Guenter,Bauer, Rupert
, p. 1607 - 1611 (2007/10/02)
Two reaction ways to 3-phenylacetyl-2-oxo-cholest-5-ene (10) as model compound for similar A-ring derivatives of steroids are investigated.The first way starts from the known 6,6-ethylenedioxy-3-oxo-5α-cholestane (1) which is reacted with phenylethinylmag
