81496-54-0

Upstream product

• 591-51-5 phenyllithium 
• 123126-64-7 N-(1-cyclopentenylmethylidene)cyclohexylamine 
• 141552-28-5 (S)-2-{[1-Cyclopent-1-enyl-meth-(E)-ylidene]-amino}-3,3-dimethyl-butyric acid tert-butyl ester 
• 131139-97-4 (1R,2R,1'R,2'R)-2'-Hydroxycyclohexyl 2-phenylcyclopentane-1-carboxylate 
• 6140-65-4 1-cyclopentene-1-carboxaldehyde 
• 854417-90-6 2-phenyl-cyclopentanecarbaldehyde 
• 123166-19-8 (1R,2R)-trans-2-phenylcyclopentanemethanol 

Downstream Products

• 81496-56-2 (1S,2S)-1-Methyl-2-phenyl-cyclopentanecarbaldehyde 
• 1173727-17-7 ethyl 3-(Z)-[(1S,2R)-2-phenylcyclopentyl]acrylate 

Relevant academic research and scientific papers

Stereoselective synthesis of (2E,4Z)-dienamides employing (triphenylphosphoranylidene)ketene

The three-component reaction between ylide Ph3PCCO, amines and aldehydes is known to afford selectively (￡)-a,ssunsaturated amides. We applied a variant of this methodology to the preparation of (2B,4Z)-dienamides 11 utilizing the phosphonium s

Design, synthesis, and application of a C2 symmetric chiral ligand for enantioselective conjugate addition of organolithium to α,β-unsaturated aldimine

A C2 symmetric chiral diether ligand, (1R,2R)-1,2-dimethoxy-1,2- diphenylethane, was designed and synthesized on the basis of the concept of an asymmetric oxygen atom. Mediated by the chiral diether, high enantioselectivities were achieved in conjugate addition of organolithiums to naphthaldehyde imine and cyclic and acyclic α,β-unsaturated aldimines. The absolute configuration of the product is predictable by the model.

Chiral alcohol-induced diastereoselective conjugate addition and cyclization

Conjugate addition of organocuprate reagents to α,β-unsaturated esters of chiral trans-cyclohexanediol proceeded diastereoselectively, and the intramolecular trapping of the generated enolate also afforded asymmetric cyclization products.

ASYMMETRIC SYNTHESIS OF 1,2-DISUBSTITUTED CYCLOALKANECARBOXALDEHYDES. PROCEDURES FOR THE HIGHLY STEREOSELECTIVE PREPARATION OF cis- AND trans-ISOMER

Procedures for the asymmetric synthesis of 1,2-disubstituted cycloalkanecarboxaldehydes (7) having asymmetric tertiary and quaternary carbon atoms in vicinal positions from the corresponding cycloalkenecarboxaldehydes (2) in high diastereomeric and enanti