815-58-7

Basic information

• Product Name: 2,3,3-trichloroacryloyl chloride
• Synonyms: 2,3,3-trichloroacryloyl chloride;trichloroacryloyl chloride;2,3,3-Trichloropropenoyl chloride
• CAS NO: 815-58-7
• Molecular Formula: C₃Cl₄O
• Molecular Weight: 193.8435
• EINECS: 212-421-9
• Mol File: 815-58-7.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 158°C (estimate)
• Flash Point: 32.8°C
• Appearance: /
• Density: 1.7155 (estimate)
• Vapor Pressure: 2.68mmHg at 25°C
• Refractive Index: 1.5271
• CAS DataBase Reference: 2,3,3-trichloroacryloyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,3-trichloroacryloyl chloride(815-58-7)
• EPA Substance Registry System: 2,3,3-trichloroacryloyl chloride(815-58-7)

Safety Data

• Hazardous Substances Data: 815-58-7(Hazardous Substances Data)

Usage

Safety Profile

Poison by inhalation. Moderatelytoxic by intraperitoneal and subcutaneous routes.Mutation data reported. A skin and eye irritant. Whenheated to decomposition it emits toxic fumes of Clí.

InChI:InChI=1/C3Cl4O/c4-1(2(5)6)3(7)8

Upstream product

• 2257-35-4 2,3,3-trichloroacrylic acid 
• 1888-71-7 perchloropropene 
• 3787-28-8 trichloro-acrylaldehyde 
• 815-14-5 1,1,2,3,3-pentachloro-3-fluoropropene 
• 87-68-3 Hexachlorobutadiene 
• 29030-84-0 1,1,2,3,3,4,4,5,6,6-decachloro-hexa-1,5-diene 

Downstream Products

• 91085-91-5 trichloro-acrylic acid-(2,4-dichloro-phenyl ester) 
• 2224-95-5 Trichloracrylsaeure-(4-nitro-phenylester) 
• 3881-57-0 trichloro-acrylic acid, pentachlorophenyl ester 
• 2224-98-8 trichloro-acrylic acid-(2,4,5-trichloro-phenyl ester) 
• 94332-35-1 4--4'-nitroazobenzol 
• 85311-90-6 1,3-dimethyl-4-(2,4-dichlorobenzoyl)-5-trichloroacryloyloxy pyrazole 
• 1228540-17-7 N,N'-p-phenylenebis(2,3,3-trichloroacrylamide) 
• 75399-39-2 2,3,3-Trichloro-1-(2-hydroxy-phenyl)-propenone 
• 133473-98-0 1-(4-methoxyphenyl)-2,3,3-trichloro-1-oxopropene 
• 133474-02-9 1-(4-tert-butylphenyl)-2,3,3-trichloro-1-oxopropene 
• 55205-24-8 Trichloracrylsaeure-phenylester 
• 34907-95-4 Trichlorvinyl-mesityl-keton 
• 958-86-1 Trichloressigsaeure-<4-methyl-7-nitro-anilid> 
• 2224-97-7 Trichloracrylsaeure-<2.4.5.6-tetrachlor-phenylester> 

Relevant articles and documents

Design, synthesis and biological evaluation of AZD9291 derivatives as selective and potent EGFRL858R/T790M inhibitors

Third-generation epidermal growth factor receptor (EGFR)L858R/T790M inhibitors are still the main drugs for the treatment of advanced non-small cell lung cancer (NSCLC), and these drugs have achieved remarkable clinical efficacy. However, there are still many patients suffering from drug-resistant mutations and drug side effects caused by NSCLC. In this study, guided by the molecular simulation, we applied a structure-based drug design strategy (SBDD) and optimized the structure to obtain a series of potent and selective EGFRL858R/T790M inhibitors. The most potent compound 18e demonstrated excellent kinase inhibitory activity and selectivity for EGFRL858R/T790M double mutants and the IC50 value reached nanomolar level. The selectivity of 18e against wild-type EGFR was near to 200-fold. In addition, compound 18e also inhibited H1975 cells proliferation at G2/M phase and induced apoptosis at a concentration of 0.25 μM, which makes it more valuable for potential lung cancer research.

Chemistry of polyhalogenated nitrobutadienes, 2: Synthesis of N-tetrachloroallylidene-N′-arylhydrazines by a formal synproportionation reaction

The reaction of 2-nitropentachlorobuta-1,3-diene with a variety of anilines substituted with electron-withdrawing groups generates, contrary to expectations, N-tetrachloroallylidene-N′-arylhydrazines instead of 1,1-bisaminated substitution products. The imidoyl-type chlorides are capable of undergoing nucleophilic substitution with amines or hydrides. The resulting compounds should exhibit physiological activity, especially for use in crop science. Georg Thieme Verlag Stuttgart.