815-59-8Relevant academic research and scientific papers
COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE
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Paragraph 0133; 0134, (2013/04/13)
The invention relates to the compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2 and X are as defined in the description and claims, which are useful for the treatment or prophylaxis of RSV infection.
COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS DISEASE
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Page/Page column 20-21, (2013/04/25)
A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1, R2 and X are as defined in description and in claims, can be used as a medicament.
Infrared and Raman spectra, vibrational assignment, and ab initio calculations of fluoromalononitrile
Dakkouri,Grunvogel-Hurst,Guirgis, Gamil A.,Yu, Zhenhong,Jin, Yanping,Durig, James R.
, p. 2001 - 2012 (2007/10/03)
The infrared spectra (3500-80 cm-1) of gaseous and solid and the Raman spectra (3500-30 cm-1) of liquid with quantitative depolarization values and solid fluoromalononitrile, FHC(CN)2, have been recorded. These spectra have been interpreted in detail and a complete vibrational assignment is proposed based on infrared band contours, depolarization values, and relative infrared and Raman intensities. The assignment is supported by a normal coordinate calculation based upon force constants obtained from MP2/6-31G* ab initio calculations. Also, from these calculations the predicted infrared and Raman spectra have been obtained. The C-H bond distance is predicted to be 1.096 A from the isolated carbon-hydrogen stretching frequency. Optimized geometric parameters have been obtained from RHF/6-31G*, MP2/6-31G* and MP2/6-311 + + G** ab initio calculations. These results are discussed and compared with those obtained for some similar molecules.
An Efficient Synthesis of Some 6-Substituted 4,8-Diaza-3,3,9,9-tetramethylundeca-2,10-dione Dioximes (Propylene Amine Oximes, PnAOs): Ligands for 99mTc Complexes Used in Structure Distribution Relationship (SDR) Studies
Nanjappan, Palaniappa,Raju, Natarajan,Ramalingam, Kondareddiar,Nowotnik, David P.
, p. 8617 - 8632 (2007/10/02)
Technetium complexes of the ligand PnAO are of interest as commercial radiopharmaceuticals.In general, PnAOs are synthesized by alkylation of a propylenediamine derivative with 3-chloro-3-methyl-2-nitrosobutane (2).This alkylation reaction proved to be low yielding.With modestly bulky substituents at the 2-position of 1,3-diaminopropane, little or none of the required PnAO was obtained.As a result, an alternative approach of the synthesis of PnAO was developed.This method involved the alkylation of the propylenediamine with 3-bromo-3-methylbutan-2-one (18) followed by oximation of the resulting diamine-diketone (19).By this method, PnAOs were prepared in good yield, even with bulky C-2 substituents.Fourteen PnAO derivatives were prepareed by this method.We also describe the syntheses of several new propylenediamine dervatives.
