81555-95-5

Upstream product

• 3690-46-8 5-(3-pyridinyl)-1,3,4-oxadiazol-2-thiol 
• 70-11-1 α-bromoacetophenone 
• 3690-46-8 5-(pyridin-3''-yl)-1,3,4-oxadiazole-2(3H)-thione 

Downstream Products

• 81556-11-8 6-Phenyl-3-pyridin-3-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 

Relevant academic research and scientific papers

The reaction of 5-aryl-(hetaryl)-2-aroylmethylthio-1,3,4-oxadiazoles with aryldiazonium tetrafluoroborates

5-Aryl(hetaryl)-2-aroylmethylthio-1,3,4-oxadiazoles behave as CH acids and readily react with aryldiazonium tetrafluoroborates at the active methylene group to give azo coupling products. The spectroscopic properties of the compounds synthesized have been

Ring Transformation of 1,3,4-Oxadiazole to s-Triazole-Fused Heterocycles. New Synthetic Route for Thiazolo-s-triazole and 7H-s-Triazolothiadiazine

s-Triazole-fused heterocycles have been synthesized by an intramolecular transformation of some 1,3,4-oxadiazole ketones with ammonia or hydrazine.The α- ketone 2m gave thiazolo-s-triazole (4m), accompanied by a small amount of the hydrazide 9m on treatment with ammonium acetate in acetic acid.Similar treatment of ketones 2a and 2b afforded only the hydrazides 9a and 9b, respectively.Ketones 2a-n reacted with hydrazine hydrate in acetic acid to give 7H-s-triazolothiadiazines 5a-n.However, ketones 2o-q, with substituents α to the carbonyl group, could not be converted to the corresponding fused-ring systems.Mechanisms for these transformations are proposed.