815575-72-5Relevant academic research and scientific papers
Radical dearomatising spirocyclisations onto the C-2 position of benzofuran and indole
Kyei, Afua S.,Tchabanenko, Kirill,Baldwin, Jack E.,Adlington, Robert M.
, p. 8931 - 8934 (2004)
New spirolactams were obtained in radical dearomatising spirocyclisations of alkyl, vinyl and aryl radicals tethered at the C-2 positions of benzofuran and indole. Spirolactams were obtained via an intramolecular radical ipso-type spirocyclisation in benzofuran and indole systems. Alkyl, vinyl and aryl radicals, tethered at the C-2 position of the heterocycle underwent radical cyclisation to produce novel tricyclic partially dearomatised heterocycles in moderate yields. Fragmentation of the furan ring was observed subsequent to spirocyclisation of a vinyl radical onto a benzofuran.
