815576-68-2 Usage
Uses
Used in Pharmaceutical Industry:
Quinolactacin A1 is used as an inhibitor of acetylcholinesterase (AChE) for its potential to modulate the cholinergic system, which can be beneficial in the treatment of neurological disorders associated with cognitive decline.
Used in Immunomodulation Applications:
Quinolactacin A1 is used as an inhibitor of TNF production to modulate the immune response and potentially treat inflammatory conditions and autoimmune diseases.
Used in Neurological Applications:
Quinolactacin A1 is used as a cognitive enhancer for its ability to inhibit acetylcholinesterase, which can improve cholinergic neurotransmission and support cognitive function in conditions such as Alzheimer's disease.
Used in Anticancer Research:
Although not explicitly mentioned in the provided materials, the inhibitory effect of Quinolactacin A1 on TNF production could potentially be explored for its role in cancer therapy, as TNF is known to have both proand anti-tumor effects depending on the context. Further research would be required to determine its applicability in this field.
Check Digit Verification of cas no
The CAS Registry Mumber 815576-68-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,5,5,7 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 815576-68:
(8*8)+(7*1)+(6*5)+(5*5)+(4*7)+(3*6)+(2*6)+(1*8)=192
192 % 10 = 2
So 815576-68-2 is a valid CAS Registry Number.
815576-68-2Relevant academic research and scientific papers
Engineered Biosynthesis of Fungal 4-Quinolone Natural Products
Liu, Mengting,Ohashi, Masao,Tang, Yi
supporting information, p. 6637 - 6641 (2020/09/02)
Quinolone-containing natural products are widely found in bacteria, fungi, and plants. The fungal quinolactacins, which are N-methyl-4-quinolones, display a wide spectrum of biological activities. Here we uncovered a concise nonribosomal peptide synthetase pathway involved in quinolactacin A biosynthesis from Penicillium by using heterologous reconstitution and in vitro enzymatic synthesis. The N-desmethyl analog of quinolactacin A was accessed through the construction of a hybrid bacterial and fungi pathway in the heterologous host.
An expedient synthesis of (+)-quinolactacin A2
Park, Su-Jin,Cho, Kwang-Nym,Kim, Won-Gon,Lee, Kee-In
, p. 8793 - 8795 (2007/10/03)
An expedient synthesis of quinolactacin A2 from N-methylisatoic anhydride and N-Boc-(2S,3S)-isoleucine has been achieved. The key step involves the Friedl?nder-type annulation of isatoic anhydride and β-ketoester derived from isoleucine.
Concise enantioselective syntheses of quinolactacins A and B through alternative winterfeldt oxidation
Zhang, Xuqing,Jiang, Weiqin,Sui, Zhihua
, p. 4523 - 4526 (2007/10/03)
Enantioselective total syntheses of (+)-quinolactacin B and (+)-quinolactacin A2 through asymmetric Pictet-Spengler cyclization and KO2 oxidation-an alternative Winterfeldt condition-are described.
