815577-89-0

Upstream product

• 619335-64-7 2-benzyloxymethyl-2-methylcyclohexane-1,3-dione 
• 815577-88-9 (2R,4aR,8aS)-hexahydro-4a-methyl-2-phenylbenzo[d][1,3]dioxin-5-one 
• 619335-62-5 (2R,3S)-2-Benzyloxymethyl-3-hydroxy-2-methyl-cyclohexanone 
• 619335-75-0 (2R,3S)-3-hydroxy-2-hydroxymethyl-2-methylcyclohexanone 

Downstream Products

• 155588-13-9 (2aR,4S,4aS,6R,11S,12S,12aR,12bS)-12-benzoyloxy-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-triethylsilyloxy-3,4,4a,5,6,9,10,11,12,12a-decahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b(2aH)diyl diacetate 
• 155588-14-0 13-deoxybaccatin III 

Relevant academic research and scientific papers

Formal total synthesis of (-)-taxol through Pd-catalyzed eight-membered carbocyclic ring formation

A formal total synthesis of (-)-taxol by a convergent approach utilizing Pd-catalyzed intramolecular alkenylation is described. Formation of the eight-membered carbocyclic ring has been a problem in the convergent total synthesis of taxol but it was solved by the Pd-catalyzed intramolecular alkenylation of a methyl ketone affording the cyclized product in excellent yield (97 %), indicating the high efficiency of the Pd-catalyzed intramolecular alkenylation. Rearrangement of the epoxy benzyl ether through a 1,5-hydride shift, generating the C3 stereogenic center and subsequently forming the C1-C2 benzylidene, was discovered and utilized in the preparation of a substrate for the Pd-catalyzed reaction.

Synthetic studies on the taxane skeleton: Construction of eight-membered carbocyclic rings by the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction

(Chemical equation presented) Construction of eight-membered carbocyclic rings via the intramolecular B-alkyl Suzuki-Miyaura cross-coupling reaction has been studied. This protocol proved its potency through the formation of the eight-membered ring posses