815578-28-0

Basic information

• Product Name: Benzonitrile, 3-[[(2R,3R)-2-methyl-4-oxo-3-azetidinyl]methyl]- (9CI)
• Synonyms: Benzonitrile, 3-[[(2R,3R)-2-methyl-4-oxo-3-azetidinyl]methyl]- (9CI)
• CAS NO: 815578-28-0
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.23648
• Product Categories: METHYL
• Mol File: 815578-28-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzonitrile, 3-[[(2R,3R)-2-methyl-4-oxo-3-azetidinyl]methyl]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-[[(2R,3R)-2-methyl-4-oxo-3-azetidinyl]methyl]- (9CI)(815578-28-0)
• EPA Substance Registry System: Benzonitrile, 3-[[(2R,3R)-2-methyl-4-oxo-3-azetidinyl]methyl]- (9CI)(815578-28-0)

Safety Data

• Hazardous Substances Data: 815578-28-0(Hazardous Substances Data)

Upstream product

• 28188-41-2 m-(bromomethyl)benzonitrile 
• 899216-39-8 (+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-(N-benzyl-N-chloroamino)butanoate 
• 899216-33-2 (-)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-(benzylamino)butanoate 
• 899216-40-1 (+)-tert-butyl (2R,3R)-2-(3-cyanobenzyl)-3-aminobutanoate 

Relevant articles and documents

Asymmetric synthesis of intermediates for otamixaban and premafloxacin by the chiral ligand-controlled asymmetric conjugate addition of a lithium amide

A chiral ligand-controlled conjugate addition reaction of lithium benzyl(trimethylsilyl)amide with tert-butyl enoates gave the corresponding lithium enolates that were then treated with electrophiles, giving anti-alkylation products with high ee up to 98%. The benzyl group on the amino nitrogen was removed by the oxidation of secondary amines to imines and subsequent transoximation to give 3-aminoalkanoates in good yields. The products are the possible key intermediates of otamixaban and premafloxacin.