81558-19-2

Basic information

• Product Name: 2,3-Dimethyl-5-(trifluoromethyl)-1H-indole
• Synonyms: 2,3-Dimethyl-5-(trifluoromethyl)-1H-indole
• CAS NO: 81558-19-2
• Molecular Formula: C₁₁H₁₀F₃N
• Molecular Weight: 213.2
• Mol File: 81558-19-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 110-111℃
• Boiling Point: 291℃
• Flash Point: 130℃
• Appearance: /
• Density: 1.269
• CAS DataBase Reference: 2,3-Dimethyl-5-(trifluoromethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dimethyl-5-(trifluoromethyl)-1H-indole(81558-19-2)
• EPA Substance Registry System: 2,3-Dimethyl-5-(trifluoromethyl)-1H-indole(81558-19-2)

Safety Data

• Hazardous Substances Data: 81558-19-2(Hazardous Substances Data)

Usage

General Description

2,3-Dimethyl-5-(trifluoromethyl)-1H-indole is a chemical compound with the molecular formula C11H10F3N. It is an indole derivative with two methyl groups and one trifluoromethyl group attached to the aromatic ring. 2,3-Dimethyl-5-(trifluoromethyl)-1H-indole is commonly used as a building block in organic synthesis and in the pharmaceutical industry for the development of potential drug candidates. It is also used as a reagent in chemical reactions due to its unique structural and electronic properties. Additionally, it has been studied for its potential biological activities, including its effects on the central nervous system and its role as an inhibitor of certain enzymes.

Upstream product

• 107-87-9 2-Pentanone 
• 368-90-1 4-(trifluoromethyl)phenylhydrazine 
• 91-55-4 2,3-dimethylindole 
• 55642-42-7 bis(trifluoromethyl)tellurium 
• 2923-56-0 4-(trifluoromethyl)phenylhydrazine hydrochloride 
• 78-93-3 butanone 

Downstream Products

• 1370410-20-0 (2,3-dimethyl-5-(trifluoromethyl)-1H-indol-1-yl)(2-iodophenyl)methanone 

Relevant articles and documents

Palladium-Catalyzed Amination/Dearomatization Reaction of Indoles and Benzofurans

This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.

Palladium-Catalyzed Dearomative Allylic Alkylation of Indoles with Alkynes to Synthesize Indolenines with C3-Quarternary Centers

A palladium-catalyzed dearomative allylic alkylation of indoles with alkynes to construct indolenines with C3-quarternary centers was reported. The in situ formed arylallene intermediate omitted the need to install leaving groups on the allylic compounds and employ extra oxidants to oxidize the allylic C-H bonds. The reaction exhibited good functional group tolerance and high atom economy. Moreover, the reaction was further expanded to synthesize pyrroloindolines and furanoindolines.

Efficient construction of fused indolines with a 2-quaternary center via an intramolecular heck reaction with a low catalyst loading

An efficient construction of fused indolines with a 2-quaternary center through a palladium-catalyzed intramolecular Heck reaction of N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided a straightforward access to diverse fused indolines with good functional group tolerance.