Ustekinumab, also known by its brand name Stelara, is a human IgG1k monoclonal antibody that specifically binds with high affinity to the p40 protein subunit shared by interleukin-12 (IL-12) and interleukin-23 (IL-23) cytokines. It is used to treat various inflammatory conditions by disrupting the IL-12 and IL-23-mediated signaling and cytokine cascades, thereby modulating the immune response.
815610-63-0
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Basic information
- Product Name: Ustekinumab
- Synonyms: ustekinumab
- CAS NO:815610-63-0
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Ustekinumab(CAS DataBase Reference)
- NIST Chemistry Reference: Ustekinumab(815610-63-0)
- EPA Substance Registry System: Ustekinumab(815610-63-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 815610-63-0(Hazardous Substances Data)
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815610-63-0 Usage
Uses
Used in Dermatology:Ustekinumab is used as a biologic treatment for plaque psoriasis, a chronic inflammatory skin disorder affecting 2-3% of the world's population. It targets the dysregulated cell growth characteristic of this condition and offers an alternative to conventional treatments like topical corticosteroids, phototherapy, and systemic drugs.
Used in Rheumatology:
In the field of rheumatology, Ustekinumab is utilized for the treatment of certain types of arthritis. It helps manage the inflammation and immune response associated with these conditions, providing relief and improving the quality of life for affected patients.
Used in Gastroenterology:
Ustekinumab is also used in gastroenterology to address certain bowel conditions characterized by inflammation. By modulating the immune system's response, it can help alleviate symptoms and promote healing in the gastrointestinal tract.
Adverse events associated with the use of Ustekinumab may include nasopharyngitis, upper respiratory tract infection, headache, fatigue, and diarrhea. However, its targeted approach to immune modulation makes it a valuable treatment option for a range of inflammatory conditions.
Originator
Medarex (US)Check Digit Verification of cas no
The CAS Registry Mumber 815610-63-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,5,6,1 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.Calculate Digit Verification of CAS Registry Number 815610-63:
(8*8)+(7*1)+(6*5)+(5*6)+(4*1)+(3*0)+(2*6)+(1*3)=150
150 % 10 = 0
So 815610-63-0 is a valid CAS Registry Number.
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Ustekinumab
