815619-73-9Relevant academic research and scientific papers
Imidazolium-based warheads strongly influence activity of water-soluble peptidic transglutaminase inhibitors
Badarau, Eduard,Mongeot, Alexandre,Collighan, Russell,Rathbone, Dan,Griffin, Martin
supporting information, p. 526 - 530 (2013/10/01)
New peptidic water-soluble inhibitors are reported. In addition to the carboxylate moiety, a new polar warhead was explored. Depending on the size of its substituents, the newly appended imidazolium scaffold designed to enhance the hydrophilic character o
Synthesis of potent water-soluble tissue transglutaminase inhibitors
Griffin, Martin,Mongeot, Alexandre,Collighan, Russell,Saint, Robert E.,Jones, Richard A.,Coutts, Ian G.C.,Rathbone, Daniel L.
body text, p. 5559 - 5562 (2009/05/30)
Dipeptide-based sulfonium peptidylmethylketones derived from 6-diazo-5-oxo-l-norleucine (DON) have been investigated as potential water-soluble inhibitors of extracellular transglutaminase. The lead compounds were prepared in four steps and exhibited pote
