815650-89-6Relevant academic research and scientific papers
Mono-acylation of piperazine and homopiperazine via ionic immobilization
Pringle, Wallace
, p. 5047 - 5049 (2008)
A method for the selective mono-acylation of piperazine and homopiperazine has been developed. In a flow system, initially the diamine is ionically immobilized on a sulfonic acid funtionalized silica gel, acylated with an appropriate reagent and finally liberated with ammonic methanol. Examples with high yield and purity are presented.
