815654-45-6Relevant academic research and scientific papers
(Thio)urea-mediated benzoxazinone opening: Mild approach towards synthesis of o-(substituted amido)benzamides
Nair, Roshna V.,Sanjayan, Gangadhar J.
, p. 7058 - 7061 (2014/02/14)
C-terminal activation of N-acylated o-aminobenzoic acids and their derivatives during coupling reactions with amines would often pose a challenge due to the formation of a benzoxazinone intermediate, which may resist reacting with amines. This communication reports a mild approach towards the installation of an amide bond via benzoxazinone ring opening utilizing Schreiner's (thio)urea organocatalyst. The Royal Society of Chemistry 2014.
