81570-50-5 Usage
Uses
Used in Biochemical Research:
GUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT is used as a substrate for studying enzyme kinetics and molecular interactions, particularly in the mechanisms of GTP-binding proteins and enzymes. Its unique configuration allows it to effectively compete with GTP, providing insights into the biological processes involving this nucleotide.
Used in Pharmaceutical Development:
In the pharmaceutical industry, GUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT is used as a tool compound to develop and test new drugs targeting GTP-binding proteins and enzymes. Its ability to interact with these proteins can help in the discovery of potential therapeutic agents for various diseases.
Used in Diagnostic Applications:
GUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT is used as a diagnostic agent to assess the activity of enzymes and proteins involved in GTP metabolism. Its competition with GTP can help in the detection and monitoring of diseases related to GTP-binding proteins and enzymes.
Used in Education and Training:
In academic and research institutions, GUANOSINE-5'-O-(1-THIOTRIPHOSPHATE), RP-ISOMER SODIUM SALT is used as an educational tool to teach students and researchers about the role of nucleotides in biological processes and the techniques used to study them. Its application in enzyme kinetics and molecular interaction studies provides hands-on experience in biochemical research.
Check Digit Verification of cas no
The CAS Registry Mumber 81570-50-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,5,7 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 81570-50:
(7*8)+(6*1)+(5*5)+(4*7)+(3*0)+(2*5)+(1*0)=125
125 % 10 = 5
So 81570-50-5 is a valid CAS Registry Number.
81570-50-5Relevant academic research and scientific papers
Ludwig, Janos,Eckstein, Fritz
, p. 631 - 635 (1989)
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one phosphitylates the 5'-hydroxy group of a nucleoside to form an intermediate (2), which on subsequent reaction with pyrophosphate produces, in a double displacement process, a P2,P3-dioxo-P1-5'-nucleosidylcyclotriphophite (3).Oxidation with sulfur gives a nucleoside 5'-(1-thiocyclotriphosphate) (4), which is hydrolyzed to the diastereomeric mixture of a nucleoside 5'-O-(1-thiotriphosphate) (5).Alternatively, 3 can be oxidized with iodine/water to furnish nucleoside 5'-triphosphates 6.This reagent can also be applied to the synthesis of nucleoside 2',3'-cyclic phosphorothioates.Protection of nucleobase functional groups is not required.
