81595-00-8 Usage
General Description
(5-P-tolyl-tetrazol-2-yl)-acetic acid is a chemical compound with the molecular formula C11H10N4O2. It is primarily used as a pharmaceutical intermediate and in the synthesis of various drugs and compounds. (5-P-TOLYL-TETRAZOL-2-YL)-ACETIC ACID is a tetrazole derivative, which is a common pharmacophore present in many pharmaceuticals due to its diverse biological activities. The acetic acid moiety in the compound makes it a useful building block for pharmaceutical synthesis, and the presence of the tolyl group provides hydrophobic properties that can potentially enhance the compound's biological potency. Overall, (5-P-tolyl-tetrazol-2-yl)-acetic acid serves as an important chemical for drug development and medicinal chemistry research.
Check Digit Verification of cas no
The CAS Registry Mumber 81595-00-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,5,9 and 5 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 81595-00:
(7*8)+(6*1)+(5*5)+(4*9)+(3*5)+(2*0)+(1*0)=138
138 % 10 = 8
So 81595-00-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H10N4O2/c1-7-2-4-8(5-3-7)10-11-13-14(12-10)6-9(15)16/h2-5H,6H2,1H3,(H,15,16)
81595-00-8Relevant articles and documents
Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators
Sharma, Swagat,Kozek, Krystian A.,Abney, Kristopher K.,Kumar, Sushil,Gautam, Nagsen,Alnouti, Yazen,David Weaver,Hopkins, Corey R.
, p. 791 - 796 (2019/02/06)
The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.
