81606-31-7Relevant academic research and scientific papers
Acyl sulfonamide anti-proliferatives. Part 2: Activity of heterocyclic sulfonamide derivatives
Mader, Mary M.,Shih, Chuan,Considine, Eileen,De Dios, Alfonso,Grossman, Cora Sue,Hipskind, Philip A.,Lin, Ho-Shen,Lobb, Karen L.,Lopez, Beatriz,Lopez, Jose E.,Cabrejas, Luisa M. Martin,Richett, Michael E.,White, Wesley T.,Cheung, Yiu-Yin,Huang, Zhongping,Reilly, John E.,Dinn, Sean R.
, p. 617 - 620 (2007/10/03)
The anti-proliferative activity of acylated heterocyclic sulfonamides is described in Vascular Endothelial Growth Factor-dependent Human Umbilical Vascular Endothelial Cells (VEGF-HUVEC) and in HCT116 tumor cells in a soft agar diffusion assay.
An Invastigation of Structure and Conformation of Thiophene-2-sulphonyl Radicals
Alberti, Angelo,Chatgilialoglu, Chryssostomos,Guerra, Maurizio
, p. 1179 - 1182 (2007/10/02)
The e.s.r. spectra of a variety of photochemically generated thiophene-2-sulphonyl radicals are described.Their spin distribution is typical of ?-radicals; radicals without substituents at position 3 exhibit relatively rapid rotation about the C-S bond at all accessible temperatures while the 3-bromo-substituted ones demonstrate a marked conformational preference which has been interpreted in terms of a ?-type conjugated structure.These findings are substantiated also by the results of INDO calculations carried out for the unsubstituted thiophene-2-sulphonyl radical with different relative arrangements of the SO2 and heteroatomic moieties.
