81606-48-6

Usage

Uses

Used in Organic Synthesis:
2-(3-Bromophenyl)-2-Methylpropan-1-ol serves as a reagent in organic synthesis, where its chemical properties facilitate the formation of new compounds through various reactions. Its presence as a bromine-substituted phenyl group makes it a valuable building block for the creation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(3-Bromophenyl)-2-Methylpropan-1-ol is utilized as an intermediate in the production of various pharmaceuticals. Its unique structure allows it to be a key component in the synthesis of drugs that target specific biological pathways or receptors, contributing to the development of novel therapeutic agents.
Used in Agrochemical Production:
2-(3-Bromophenyl)-2-Methylpropan-1-ol also finds application in the agrochemical industry, where it is used as an intermediate in the synthesis of pesticides and other agricultural chemicals. Its chemical properties make it suitable for the development of compounds that can effectively control pests and diseases in crops.
Used in Fragrance and Flavoring Compounds Manufacturing:
2-(3-BroMophenyl)-2-Methylpropan-1-ol's unique aroma and flavor profile make it a valuable ingredient in the production of fragrances and flavoring compounds. It is used to create a wide range of scents and tastes for various consumer products, from perfumes and cosmetics to food and beverages.

Upstream product

• 251458-15-8 methyl 2-(3-bromophenyl)-2-methylpropanoate 
• 81606-47-5 2-(3-bromophenyl)-2-methylpropanoic acid 

Relevant academic research and scientific papers

Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br?nsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

MACROCYCLIC FACTOR VIIA INHIBITORS

The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are Factor VIIa inhibitors which may be used as medicaments.

4-AMINO-7,8-DIHYDROPYRIDO[4,3-d]PYRIMIDIN-5(6H)-ONE DERIVATIVES

The invention provides compounds of the general Formula (I) where R1, R2, and A are defined herein, as well as the preparation, compositions and uses thereof.

Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H- indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management

Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here we report that replacement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-N′-benzyl urea series led to a number of TRPV1 antagonists with significantly increased in vitro potency and enhanced drug-like properties. Extensive evaluation of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted in identification of (R)-7 (ABT-102). Both the analgesic activity and drug-like properties of (R)-7 support its advancement into clinical pain trials.

QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.