81608-59-5

Basic information

• Product Name: methyl (4xi,11beta,12alpha,13beta,15beta)-2,3,11,12,16-pentahydroxy-15-[(3-methylbutanoyl)oxy]-13,20-epoxypicrasan-21-oate
• CAS NO: 81608-59-5
• Molecular Formula: C₂₆H₄₀O₁₁
• Molecular Weight: 528.5892
• Mol File: 81608-59-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 654.1°C at 760 mmHg
• Flash Point: 212.7°C
• Density: 1.41g/cm³
• Vapor Pressure: 7E-20mmHg at 25°C
• Refractive Index: 1.594
• CAS DataBase Reference: methyl (4xi,11beta,12alpha,13beta,15beta)-2,3,11,12,16-pentahydroxy-15-[(3-methylbutanoyl)oxy]-13,20-epoxypicrasan-21-oate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (4xi,11beta,12alpha,13beta,15beta)-2,3,11,12,16-pentahydroxy-15-[(3-methylbutanoyl)oxy]-13,20-epoxypicrasan-21-oate(81608-59-5)
• EPA Substance Registry System: methyl (4xi,11beta,12alpha,13beta,15beta)-2,3,11,12,16-pentahydroxy-15-[(3-methylbutanoyl)oxy]-13,20-epoxypicrasan-21-oate(81608-59-5)

Safety Data

• Hazardous Substances Data: 81608-59-5(Hazardous Substances Data)

Upstream product

• 14907-98-3 Brusatol 
• 25514-31-2 brucein A 
• 77702-23-9 tetrahydrobrusatol 

Relevant articles and documents

Antitumor agents XLV: Bisbrusatolyl and brusatolyl esters and related compounds as novel potent antileukemic agents

A series of new bisbrusatolyl and brusatolyl esters and related compounds were synthesized and tested for in vivo antileukemic activity against a quassinoid sensitive strain of P-388 lymphocytic leukemia in BDF1 mice. The bisbrusatolyl malonate, succinate, glutarate, adipate, and sebacate were as active or more active than brusatol. The C-3 esters of brusatol and bruceantin were also found to be as active or more active than brusatol or bruceantin in general. The free hydroxyl groups at C-11 and C-12 as well as the enone double bond in ring A of both bisbrusatolyl and brusatolyl esters are required for antileukemic activity. The presence of a double bond in the ester side chain contributes to the enhanced activity of these esters.