81617-09-6Relevant articles and documents
7-(2-AMINOETHYL) BENZOTHIAZOLONES
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, (2008/06/13)
There are disclosed compounds of formula I, Ar--CH. sub.2 CH 2--NH--CR 1 R 2--X--Y I in whichAr represents a group, STR1 X represents a C. sub.1-12 alkylene chain optionally interrupted or terminated by one or more groups selected from--S(O) n--,--O--,--C(Z)--, CR 6 R. sup.7, phenylmethyne,--NR 8--,--CONH--,--NHCO--and--NHCONH--, Y represents an optionally substituted aryl or cycloalkyl group,Z represents O or S, R 1, R 2, R 5 and R 9 each independently represent hydrogen or alkyl C 1-6,R 3 and R 4 represent hydrogen, or R. sup.3 and R 4 together form a group--S--,--NR 9--or--CH 2--,R 6 and R 7 independently represent hydrogen, alkyl C 1-6, fluoro, cyano, or CF. sub.3, provided that at least one of R 6 and R 7 is other than hydrogen,R 8 represents hydrogen or alkyl C 1-6, or when X is interrupted or terminated by more than one--NR 8--group may together with another R 8 group form the chain--CH 2--CH 2--, andn represents 0, 1 or 2,and pharmaceutically acceptable derivatives thereof.Processes for their production and pharmaceutical compositions and methods of treatment involving their use are also described.
Reaction of 2-Methoxyethyl Hemiacetals with Allylsilanes in the Presence of Titanium Tetrachloride: Regioselective C-O Bond Cleavage of the Unsymmetrical Acetals
Nishiyama, Hisao,Itoh, Kenji
, p. 2496 - 2498 (2007/10/02)
Reaction of 2-methoxyethyl hemiacetals with allylsilanes in the presence of titanium tetrachloride gave the corresponding homoallyl ethers in good yields by the regioselective C-O bond cleavage of the hemiacetals.A new carbon homologative cyclization was
Reaction of Allylsilanes and Monothioacetals in the Presence of Lewis Acids: Regioselectivity in the Cleavage of the Acetals
Nishiyama, Hisao,Narimatsu, Shinzo,Sakuta, Koji,Itoh, Kenji
, p. 459 - 460 (2007/10/02)
Trimethylallylsilane reacts with monothioacetals in the presence of tin(IV) chloride, titanium tetrachloride, or boron trifluoride-diethyl ether to give the homoallyl ethers and homoallyl sulphides.