81617-09-6Relevant articles and documents
7-(2-AMINOETHYL) BENZOTHIAZOLONES
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, (2008/06/13)
There are disclosed compounds of formula I, Ar--CH. sub.2 CH 2--NH--CR 1 R 2--X--Y I in whichAr represents a group, STR1 X represents a C. sub.1-12 alkylene chain optionally interrupted or terminated by one or more groups selected from--S(O) n--,--O--,--C(Z)--, CR 6 R. sup.7, phenylmethyne,--NR 8--,--CONH--,--NHCO--and--NHCONH--, Y represents an optionally substituted aryl or cycloalkyl group,Z represents O or S, R 1, R 2, R 5 and R 9 each independently represent hydrogen or alkyl C 1-6,R 3 and R 4 represent hydrogen, or R. sup.3 and R 4 together form a group--S--,--NR 9--or--CH 2--,R 6 and R 7 independently represent hydrogen, alkyl C 1-6, fluoro, cyano, or CF. sub.3, provided that at least one of R 6 and R 7 is other than hydrogen,R 8 represents hydrogen or alkyl C 1-6, or when X is interrupted or terminated by more than one--NR 8--group may together with another R 8 group form the chain--CH 2--CH 2--, andn represents 0, 1 or 2,and pharmaceutically acceptable derivatives thereof.Processes for their production and pharmaceutical compositions and methods of treatment involving their use are also described.
Reaction of Allylsilanes and Monothioacetals in the Presence of Lewis Acids: Regioselectivity in the Cleavage of the Acetals
Nishiyama, Hisao,Narimatsu, Shinzo,Sakuta, Koji,Itoh, Kenji
, p. 459 - 460 (2007/10/02)
Trimethylallylsilane reacts with monothioacetals in the presence of tin(IV) chloride, titanium tetrachloride, or boron trifluoride-diethyl ether to give the homoallyl ethers and homoallyl sulphides.
Reaction of 2-Methoxyethyl Hemiacetals with Allylsilanes in the Presence of Titanium Tetrachloride: Regioselective C-O Bond Cleavage of the Unsymmetrical Acetals
Nishiyama, Hisao,Itoh, Kenji
, p. 2496 - 2498 (2007/10/02)
Reaction of 2-methoxyethyl hemiacetals with allylsilanes in the presence of titanium tetrachloride gave the corresponding homoallyl ethers in good yields by the regioselective C-O bond cleavage of the hemiacetals.A new carbon homologative cyclization was