81626-21-3

Upstream product

• 81626-19-9 (+)-norephedrine formate 
• 37577-28-9 (1S,2R)-(+)-norphedrine 
• 2258-42-6 formyl acetic anhydride 
• 37577-07-4 Norpseudoephedrine 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 76333-53-4 (+)-(2R)-2-Amino-1-phenyl-1-propanone hydrochloride 
• 112681-13-7 (1S,2R)-2-isocyano-1-phenylpropyl acetate 
• 214678-96-3 (1R,2S,1'S)-(+)-N-<1-methyl-2-(2'-methyl-1'-nitromethylpropoxy)-2-phenylethyl>formamide 
• 81626-22-4 (+)-N-formyl-α-aminopropiophenone 
• 112681-09-1 (1S,2R)-2-formamido-1-phenylpropyl acetate 

Relevant academic research and scientific papers

N-ALKYLOXAZABOROLIDINES DERIVED FROM EPHEDRINES

The synthesis of oxazaborolidines from amides derived from ephedrine and pseudoephedrine by treatment with BH3-THF is reported.The reaction affords chiral oxazaborolidines with nitrogen atom substituents of different steric requirements enlarging the pote

Scope and Limitations of the TiCl4-Mediated Additions of Isocyanides to Aldehydes and Ketones with Formation of α-Hydroxycarboxylic Acid Amides

The adducts obtained from TiCl4 and achiral (8-12) or chiral, nonracemic (13-22) isocyanides are combined with aldehydes (aromatic or aliphatic) and ketones (acetone, cyclohexanone, acetophenone) to give, after aqueous workup, α-hydroxyamides (27-55) .The transformation is compatible with a variety of functional groups (aromatic and heterocyclic rings, amino, ether, ester, and amido groups, halides, and phosphonate substituents).The yields range from 14 to over 95percent (with the lower values in the case of more highly functionalised isocyanides).No diastereoselectivity is observed with chiral isocyanides.If the R groups of the isocyanide (R-NC) form a rather stable cation (t-alkyl or benzylic), cyanohydrins may result from the reaction, rather than the N-substituted α-hydroxyamides (see Scheme 2).