81635-45-2Relevant academic research and scientific papers
Scandium (III)-Catalyzed Cycloaddition of in situ Generated ortho-Quinone Methides with Vinyl Azides: An Efficient Access to Substituted 4H-Chromenes
Thirupathi, Nuligonda,Tung, Chen-Ho,Xu, Zhenghu
, p. 3585 - 3589 (2018)
A convenient and practical synthesis of 4H-chromenes from the readily accessible o-hydroxybenzhydryl alcohols and vinyl azides has been achieved. The transformation proceeds through a cascade that involves formation of an ortho-quinone methide, [4+2]-cycloaddition and elimination of hydrazoic acid. The reaction is well tolerated with respect to both the o-hydroxybenzhydrols and the vinyl azides and affords the products in moderate to good yields. (Figure presented.).
