816452-41-2Relevant academic research and scientific papers
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase
Vanheusden, Veerle,Munier-Lehmann, Hélène,Froeyen, Matheus,Busson, Roger,Rozenski, Jef,Herdewijn, Piet,Van Calenbergh, Serge
, p. 6187 - 6194 (2007/10/03)
Thymidine monophosphate kinase of Mycobacterium tuberculosis (TMPKmt) represents an attractive target for selectively blocking bacterial DNA synthesis. Hereby, we report on the discovery of a novel class of bicyclic nucleosides (10 and 11) and one dinucle
