816454-25-8

Basic information

• Product Name: 1,2-dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylate
• Synonyms: 1,2-dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylate;(3S)-Tetrahydro-1,2,3-pyridazinetricarboxylic acid 1,2-bis(phenylmethyl) ester
• CAS NO: 816454-25-8
• Molecular Formula: C₂₁H₂₂N₂O₆
• Molecular Weight: 454.5155
• Mol File: 816454-25-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Density: 1.339
• CAS DataBase Reference: 1,2-dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylate(816454-25-8)
• EPA Substance Registry System: 1,2-dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylate(816454-25-8)

Safety Data

• Hazardous Substances Data: 816454-25-8(Hazardous Substances Data)

Usage

General Description

1,2-dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylate is a chemical compound with a complex structure that includes a piperazine ring and three carboxylate groups. It is also known as TASP0437128-002, and it is commonly used as a synthetic intermediate in the production of pharmaceuticals and organic compounds. 1,2-dibenzyl 3-tert-butyl piperazine-1,2,3-tricarboxylate has been studied for its potential pharmacological properties, including its ability to act as a modulator of certain receptors and enzymes in the body. It is important to handle this compound with care, as it may have hazardous properties and should only be used by qualified individuals in a controlled laboratory setting.

Upstream product

• 2449-05-0 dibenzyl azodicarboxylate 
• 1191-30-6 5-bromopentanal 
• 816454-06-5 (S)-2-(N,N'-dibenzyloxycarbonylhydrazino)-5-bromo-1-(tert-butyldimethylsiloxy)pentane 
• 816454-12-3 (S)-1,2-dibenzyloxycarbonyl-3-(tert-butyldimethylsiloxymethyl)tetrahydropyridazine 
• 816454-01-0 (S)-5-bromo-2-N,N'-dibenzyloxycarbonylhydrazino-1-pentanol 
• 2449-05-0 dibenzyl azodicarboxylate 
• 816454-17-8 (S)-1,2-dibenzyloxycarbonyl-3-hydroxymethyl-tetrahydropyridazine 

Relevant articles and documents

A scalable process to the key intermediate of cilazapril, (S)-1-benzyloxycarbonylhexahydropyridazine-3-carboxylic acid, through a novel cascade course

A novel and efficient manufacturing technology is disclosed in the present work for the preparation of (S)-1-benzyloxycarbonylhexahydropyridazine-3- carboxylic acid, which is a key intermediate of cilazapril. The whole process includes only three steps; the first two steps were conducted in one pot, followed by a novel selective removal of a Cbz group in a cascade course.

Remarkable effects of titanium tetrachloride in diastereoselective aza Diels-Alder cycloaddition: Synthesis of (S)-piperazic acid

Titanium tetrachloride-mediated aza Diels-Alder cycloaddition using a chiral diene and an aza dienophile proceeds in highly diastereoselective manner to form a dehydropiperazic acid derivative in high yield, and diastereoselectivity of the reaction depends on the quantity of titanium tetrachloride.