816468-41-4 Usage
Molecular Weight
308.42 g/mol
Structure
A derivative of piperidine with a tert-butoxycarbonyl (Boc) group at the 1-position and a 2-methoxyphenylamino group at the 3-position.
Functional Groups
a. Boc (tert-butoxycarbonyl) group
b. Amino group
c. Methoxy group
d. Phenyl ring
Appearance
Likely a solid or crystalline substance (not specified in the material)
Solubility
Not specified in the material, but likely soluble in organic solvents like methanol, ethanol, or acetone due to its nonpolar nature.
Stability
Stable under normal conditions, but sensitive to strong acids or bases which can remove the Boc protecting group.
Reactivity
a. Can undergo reactions involving the amino group, such as acylation, alkylation, or reductive amination.
b. The Boc group can be removed using strong acids to reveal the free amino group.
c. The methoxy group and phenyl ring can participate in various electrophilic aromatic substitution reactions.
Applications
a. Building block in organic synthesis for the preparation of pharmaceuticals and organic compounds.
b. Used in the synthesis of potential drug candidates and other biologically active molecules.
c. Potentially useful in medicinal chemistry and drug discovery research due to the presence of the 2-methoxyphenylamino group.
Hazards
Not specified in the material, but should be handled with care due to its reactivity and potential biological activity. Appropriate safety measures should be taken during handling and storage.
Check Digit Verification of cas no
The CAS Registry Mumber 816468-41-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,6,4,6 and 8 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 816468-41:
(8*8)+(7*1)+(6*6)+(5*4)+(4*6)+(3*8)+(2*4)+(1*1)=184
184 % 10 = 4
So 816468-41-4 is a valid CAS Registry Number.
816468-41-4Relevant articles and documents
Palladium-mediated arylation of 3-aminopiperidines and 3-aminopyrrolidines
Jean, Ludovic,Rouden, Jacques,Maddaluno, Jacques,Lasne, Marie-Claire
, p. 8893 - 8902 (2007/10/03)
This paper describes the palladium-catalyzed arylation of 1-substituted 3-aminopyrrolidines or piperidines. Palladium(0) (1-2 mol %) in conjunction with "Buchwald's ligand" [2-(dimethylamino)-2′- (dicyclohexylphosphine)biphenyll was shown to be the catalyst of choice for the coupling with aryl bromides or chlorides. When bromobenzene was used, a strong temperature effect was noticed. Whereas no reaction occurred at 100 °C, yields higher than 85% were obtained at 130 °C for each substrate. Such an effect was not observed when diphosphines were used. Whereas Xantphos and, to a lesser extent BINAP, were moderately efficient in the coupling of all diamines, the palladium-mediated arylation in the presence of monophosphines was strongly dependent on the substrate. The results suggest the participation of both nitrogens of the aminoheterocycle in the reactive intermediate. This participation could also account for the highly selective arylation of the endocyclic nitrogen of unsubstituted 3-aminopyrrolidine or piperidine. Optimal conditions were found for the arylation using 2- or 4-substituted electron-poor or enriched aryl halides.
