81649-60-7

Upstream product

• 76934-57-1 2-(3-Methoxy-benzoyl)-3-(4-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester 
• 76934-57-1 (2S,3S)-2-(3-Methoxy-benzoyl)-3-(4-methoxy-phenyl)-cyclopropanecarboxylic acid ethyl ester 
• 76934-57-1 ethyl 2-(4-methoxyphenyl)-3-(3-methoxyphenylcarbonyl)-cyclopropanecarboxylate 
• 76934-57-1 ethyl 2-(4-methoxyphenyl)-3-(3-methoxyphenylcarbonyl)-cyclopropanecarboxylate 

Downstream Products

• 81649-59-4 1,2,3,4-tetrahydro-6-methoxy-1-(4-methoxyphenyl)-4-oxonaphthalene-2-carboxylic acid 
• 81649-63-0 1,3,3a,4,9,9a-hexahydro-4-hydroxy-3a-hydroxymethyl-6-methoxy-9-(4-methoxyphenyl)-naphtho<2,3-c>furan-1-one 

Relevant academic research and scientific papers

Total Synthesis of ( +/-)-Picropodophillone

Following model studies, the synthesis of (+/-)-picropodophillone was completed by first cyclopropanating the appropriate chalcone (11) with ethoxycarbonyl dimethylsulphonium methylide.Treatment of the resulting cyclopropyl ketone with stannic chloride in

Lewis Acid-catalysed Reactions of Aryl Cyclopropyl Ketones. Scope and Mechanism

The effects of aryl substituents on the stannic chloride-catalysed cyclisation of aryl cyclopropyl ketones (1) to aryl tetralones (2) are consistent with the formation of a benzyl carbocation intermediate (8) or a cyclic oxonium ion intermediate (12).The

TRAPPING THE INTERMEDIATE INVOLVED IN THE INTRAMOLECULAR CYCLISATION OF CYCLOPROPYL KETONES. A CONVENIENT PREPARATION OF OPEN-CHAIN γ-HYDROXY KETONES.

The concerted mechanism for the stannic chloride catalysed cyclisation of aryl cyclopropyl ketones is disproved by trapping the intermediate.The reaction provides a facile route to γ-hydroxyketones.