81653-77-2

Usage

Uses

Used in Pharmaceutical Industry:
Cis-4-phenylthio-L-proline (Zofenopril Intermediate) is used as a key intermediate in the synthesis of Zofenopril for its role in the treatment of high blood pressure and congestive heart failure. As an ACE inhibitor, Zofenopril helps regulate blood pressure by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thus promoting vasodilation and reducing the workload on the heart.
Used in Medicinal Chemistry Research:
Cis-4-phenylthio-L-proline (Zofenopril Intermediate) serves as a valuable compound in medicinal chemistry research for the development of new ACE inhibitors or other related pharmaceuticals. Its unique structure and properties make it a promising candidate for further exploration and modification to improve the efficacy and safety of treatments for cardiovascular diseases.
Used in Drug Manufacturing Process:
Cis-4-phenylthio-L-proline (Zofenopril Intermediate) is utilized in the drug manufacturing process as an essential component in the production of Zofenopril. Its synthesis and incorporation into the final drug product are critical steps in ensuring the therapeutic effectiveness of Zofenopril in managing high blood pressure and congestive heart failure.

Downstream Products

• 81872-10-8 zofenopril 
• 126111-05-5 4-phenylsulfanylpyrrolidine-2-carboxylic acid methyl ester 
• 83551-92-2 1-[N-(1-(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanyl]-4-(S)-(phenylthio)-L-proline 
• 113949-54-5 C₂₉H₄₀N₂O₅SSi 
• 113949-43-2 N-<<(1,1-dimethylethyl)oxy>carbonyl>-cis-4-(phenylthio)-L-proline (trimethylsilyl)ethyl ester 
• 113949-53-4 (2S,4S)-4-Phenylsulfanyl-pyrrolidine-2-carboxylic acid 2-trimethylsilanyl-ethyl ester 
• 681248-39-5 (4S)-1-[(R)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester 
• 681144-92-3 (4S)-1-(2-methylpropenoyl)-4-phenylthio-L-proline methyl ester 
• 75176-37-3 Zofenoprilat 
• 113949-52-3 (4S)-1-[(S)-3-benzoylthio-2-methylpropanoyl]-4-phenylthio-L-proline methyl ester 
• 75176-36-2 (1S,4S)-1-<3-(acetylthio)-2-methyl-1-oxopropyl>-4-(phenylthio)-L-proline 
• 83623-88-5 (2S,4S)-4-(phenylsulfanyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 

Relevant academic research and scientific papers

PROLINE DERIVATIVES HAVING AFFINITY FOR THE CALCIUM CHANNEL ALPHA-2-DELTA SUBUNIT

The compounds of formula (I) or a pharmaceutically acceptable salt, solvate or pro-drug thereof, are proline derivatives useful in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, fibromyalgia, arthritis, neuropathalogical disorders, sleep disorders, visceral pain disorders and gastrointestinal disorders. Processes for the preparation of the final products and intermediates useful in the process are included. Pharmaceutical compositions containing one or more of the compounds are also included. Wherein either X is O, S, NH or CH2 and Y is CH2 or a direct bond, or Y is O, S or NH and X is CH2; and R is a 3-12 membered cycloalkyl, 4-12 membered heterocycloalkyl, heteroaryl or aryl, where any ring may be optionally substituted with one or more substituents independently selected from halogen, hydroxy, cyano, nitro, amino, hydroxycarbonyl, Cl-C6 alkyl, Cl-C6 alkenyl, CI-C6 alkynyl, Cl-C6 alkoxy, hydroxyC,-C6 alkyl, Cl-C6 alkoxyC,-C6 alkyl, perfluoro Cl-C6 alkyl, perfluoroC,-C6 alkoxy, Cl-C6 alkylamino, di- C1-C6 alkylamino, aminoC1-C6 alkyl, Cl-C6 alkylaminoC,-C6 alkyl, di-Cl-C6 alkylaminoC,-C6 alkyl, CI-C6acyl, C1-C6acyloxy, Cl-C6acyloxyC,-C6 alkyl, Cl-C6 acylamino, Cl-C6 alkylthio, C1-C6 alkylthiocarbonyl, C1-C6 alkylthioxo, C1-C6 alkoxycarbonyl, Cl-C6 alkylsulfonyl, C1-C6 alkylsulfonylamino, aminosulfonyl, Cl-C6 alkylaminosulfonyl, di-Cl-C6 alkylaminosulfonyl, 3-8 membered cycloalkyl, 4-8 membered heterocycloalkyl, phenyl and monocyclic heteroaryl; or a pharmaceutically acceptable salt, solvate or pro-drug thereof.