81683-45-6Relevant academic research and scientific papers
A ONE-POT AND SELECTIVE PREPARATION OF 2-(N-ALKYL-4-CHLOROBUTYLAMINO)-4-CHLOROQUINAZOLINES
Miki, Hideki
, p. 7 - 9 (2007/10/02)
A new and facile synthesis of 2-(N-alkyl-4-chlorobutylamino)-4-chloroquinazolines by the reaction of 2,4(1H,3H)-quinazolinedione with N-alkylpyrrolidines in phosphoryl chloride is described.
Fused Pyrimidines. I. The Chlorination of 2,4(1H,3H)-Quinazolinedione with Phosphoryl Chloride in the Presence of N-Alkylcyclic Amines
Miki, Hideci
, p. 1947 - 1951 (2007/10/02)
In the reaction of 2,4(1H,3H)-quinazolinedione with phosphoryl chloride in the presence of excess N-methylpyrrolidine, the hydroxy groups at the 2- and 4-position of the quinazoline nucleus were replaced by the N-methyl-4-chlorobutylamino group and chlorine to give 4-chloro-2-(N-methyl-4-chlorobutylamino)quinazoline in good yield.By using this reaction, several new 4-chloro-2-dialkylaminoquinazoline derivatives were obtained from N-alkylcyclic amines and 2,4(1H,3H)-quinazolinedione.Keywords --- N-alkylcyclic amine; pyrrolidine; piperidine; 2,4(1H,3H)-quinazolinedione; chlorination; amination; substitution reaction; ammonium salt; 4-chloro-2-dialkylaminoquinazoline
