81684-80-2

Usage

Explanation

The molecular formula represents the compound's composition, with 7 carbon atoms, 11 hydrogen atoms, 2 nitrogen atoms, and 1 hydrogen chloride molecule.

Explanation

The structure consists of a benzene ring with two amine groups (NH2) at the 1 and 2 positions, a methyl group (CH3) attached to the nitrogen at the 1 position, and a hydrogen chloride molecule.

Explanation

1,2-Benzenediamine,N1-methyl-, hydrochloride (1:1) is mainly used in the manufacturing of hair dyes due to its ability to react with hair proteins and change the hair color.

Explanation

The compound can also be used as a building block or intermediate in the synthesis of other organic compounds.

Explanation

The compound has been shown to cause irritation to the skin and eyes upon contact. Ingestion or inhalation of the compound can lead to toxic effects on human health.

Explanation

To minimize exposure and potential health risks, individuals working with or around this chemical should use appropriate personal protective equipment (PPE) such as gloves, goggles, and masks, as well as follow safety protocols and guidelines.

Primary Use

Production of hair dyes

Additional Applications

Synthesis of various organic compounds

Health Hazards

Skin and eye irritation, toxicity if ingested or inhaled

Safety Precautions

Use of appropriate protective equipment and measures

Upstream product

• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 612-28-2 2-nitro-N-methylaniline 

Downstream Products

• 81684-73-3 8-methylnaphtho<1',2':5,6>pyrano<2,3-b><1,5>benzodiazepin-15-(8H)one 
• 884330-09-0 desmethyl dibenzimidazole 
• 884330-18-1 7-methyl-2-propyl-3H-benzoimidazole-5-carboxylic acid(2-methylaminophenyl)amide 
• 884330-17-0 3-amino-4-butyrylamino-5-methyl-N-(2-methylaminophenyl)benzamide 
• 152628-02-9 2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole 

Relevant academic research and scientific papers

Synthesis method of N-methyl-1,2-benzenediamine dihydrochloride

The invention discloses a synthesis method of N-methyl-1,2-benzenediamine dihydrochloride. The synthesis method is characterized by comprising the following steps that 1, o-chloronitrobenzene and a monomethylamine aqueous solution are subjected to a sealing reaction, after the reaction is completed, cooling, standing and layering are conducted, and a lower-layer oil phase is collected to obtain N-methyl-2-nitroaniline; 2, a catalyst is added to a mixed solution of ethyl alcohol and the N-methyl-2-nitroaniline obtained in step 1, after mixing and heating, hydrazine hydrate is slowly dropwise added to the mixed solution, and after drop addition is completed, a heat preservation reaction is conducted; after the reaction is completed, suction filtration is conducted, and a suction filtration mother solution is reserved to obtain N-methyl-o-phenylenediamine; 3, liquid caustic soda, water and EDTA are added to the N-methyl-o-phenylenediamine obtained in step 2 for mixing, after cooling is conducted, dichloromethane is added, stirring, extraction, standing and layering are conducted, a lower-layer oil phase is collected, and through separation and purification, the target product N-methyl-1,2-benzenediamine dihydrochloride is obtained. The N-methyl-1,2-benzenediamine dihydrochloride product prepared through the method has high purity and few impurities and can be widely applied to the field of intermediate synthesis of a medicine tishamitan for reducing the blood pressure.

An efficient and impurity-free process for telmisartan: An antihypertensive drug

Telmisartan (1), a substituted dibenzimidazole derivative, is an antihypertensive drug, essentially used to control blood pressure. An improved, cost-effective, and impurity-free process for telmisartan (1) suitable for large-scale production is described here by addressing various process development issues. The overall yield obtained from this newly developed process is around 50% (over five steps) compared to the literature reported process (21%, over eight steps).