81698-80-8Relevant academic research and scientific papers
Studies on Intramolecular Cycloaddition Reactions of Some Isoquinolinium Salts
Gisby, Graham P.,Sammes, Peter G.,Watt, Robert A.
, p. 249 - 256 (2007/10/02)
Thermally-induced intramolecular addition reactions of isoquinolinium derivatives bearing an alkenyl side-chain have been studied.Cycloadditions can occur across the isolated olefinic bond and the 1,4-positions of the isoquinolinium system to produce tetracyclic adducts.The chemistry of these adducts is compared with that of cycloadducts produced in intramolecular additions.Preparation of some of the isoquinoline derivatives involved alkylation of the parent base; 3-metylisoquinoline can be substituted either at the methyl group, upon reaction with aromatic nitriles or at C-4, using alkyl halides.
