81703-55-1 Usage
Description
Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 μg/kg/min. In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 μg/kg/min and 60 ng/ml, respectively.
Check Digit Verification of cas no
The CAS Registry Mumber 81703-55-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,7,0 and 3 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 81703-55:
(7*8)+(6*1)+(5*7)+(4*0)+(3*3)+(2*5)+(1*5)=121
121 % 10 = 1
So 81703-55-1 is a valid CAS Registry Number.
InChI:InChI=1/2C22H36O4.Ca/c2*1-3-4-5-9-17(23)11-12-18-19-13-16(8-6-7-10-21(25)26)14-22(19,2)15-20(18)24;/h2*8,11-12,17-20,23-24H,3-7,9-10,13-15H2,1-2H3,(H,25,26);/q;;+2/p-2/b2*12-11+,16-8-;/t2*17-,18+,19+,20+,22-;/m00./s1
81703-55-1Relevant articles and documents
Synthesis of 9-Substituted Carbacyclin Analogues
Aristoff, Paul A.,Johnson, Paul D.,Harrison, Allen W.
, p. 5341 - 5348 (2007/10/02)
The synthesis of a series of 9-substituted carbacyclin analogues with potent platelet antiaggregatory activity is described.The key step for the formation of 9-acetylene compounds (e. g., 8d) utilized a modification of the Schwartz procedure involving the nickel-catalyzed conjugate addition of the appropriate alkynyl aluminate to bicyclooct-1-en-3-one (2).It was found that 9-methylcarbacyclin (8b) could be prepared by a similar procedure.In addition, a novel alternative to the Wittig reaction for introducing the carbacyclin upper side chain in base-sensitive substrates was developed which involves the addition of the dianion of 6-((tert-butyldimethylsilyl)oxy)hexanoic acid to the appropriate ketone (e. g., 6f or 2) followed by decarboxylative dehydration of the resulting β-hydroxy acid.
