81705-06-8 Usage
General Description
18-hydroxycortisol is a steroid hormone that is produced by the adrenal cortex and is a metabolite of cortisol. It is synthesized through the action of the enzyme 11β-hydroxylase and plays a role in the regulation of the body's response to stress and its overall metabolism. 18-hydroxycortisol has been implicated in conditions such as hypertension and Cushing's syndrome, and its levels can be measured in the blood or urine to assess adrenal function and diagnose related disorders. Research also suggests that this chemical may have potential applications in the treatment and management of certain endocrine disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 81705-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,7,0 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 81705-06:
(7*8)+(6*1)+(5*7)+(4*0)+(3*5)+(2*0)+(1*6)=118
118 % 10 = 8
So 81705-06-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H10O4/c1-2-3(6)4(7)5(8)9/h3-4,6-7H,2H2,1H3,(H,8,9)
81705-06-8Relevant articles and documents
Convenient synthesis of 18-hydroxylated cortisol and prednisolone
Kurosawa, Takao,Ikegawa, Shigeo,Chiba, Hitoshi,Ito, Yoshito,Nakagawa, Syoichi,Kobayashi, Kunihiko,Tohma, Masahiko
, p. 426 - 429 (2007/10/02)
18,20-Epoxy-11β,17α,20β,21-tetrahydroxypregn-4-en-3-one was synthesized by the application of hypoiodite reaction to the cortisol acetonide. The intermediary 18-iodo derivative was converted to the 11-oxo steroid by chromic acid prior to silver ion-assisted solvolysis. Removal of the protective group with hydrochloric acid was finally carried out to give the desired 11β,17α,18,21-tetrahydroxypregn-4-ene3,20-dione as the hemiacetal form. 18,20-Epoxy-11β-17α,20β,21-tetrahydroxypregna-1,4-dien-3-one was also prepared from prednisolone through a similar reaction sequence.
