81705-06-8 Usage
Uses
Used in Endocrine Disorder Management:
18-hydroxycortisol is used as a diagnostic marker for assessing adrenal function and diagnosing endocrine disorders such as hypertension and Cushing's syndrome. Its measurement in blood or urine helps in evaluating the body's response to stress and overall metabolism.
Used in Pharmaceutical Research:
18-hydroxycortisol is used as a target for research in the development of treatments and management strategies for endocrine disorders. Its potential applications in this field are being explored to improve patient outcomes and address the underlying causes of these conditions.
Used in Clinical Diagnostics:
In the clinical diagnostics industry, 18-hydroxycortisol is used as a biomarker for the assessment of adrenal function. Its levels in blood or urine provide valuable information for the diagnosis and monitoring of endocrine disorders, aiding healthcare professionals in making informed decisions regarding patient care.
Used in Drug Development:
In the pharmaceutical industry, 18-hydroxycortisol is used as a target for drug development, with the aim of creating new treatments for endocrine disorders. Research into its role in these conditions may lead to the discovery of novel therapeutic agents that can effectively manage or treat these disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 81705-06-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,7,0 and 5 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 81705-06:
(7*8)+(6*1)+(5*7)+(4*0)+(3*5)+(2*0)+(1*6)=118
118 % 10 = 8
So 81705-06-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H10O4/c1-2-3(6)4(7)5(8)9/h3-4,6-7H,2H2,1H3,(H,8,9)
81705-06-8Relevant academic research and scientific papers
Convenient synthesis of 18-hydroxylated cortisol and prednisolone
Kurosawa, Takao,Ikegawa, Shigeo,Chiba, Hitoshi,Ito, Yoshito,Nakagawa, Syoichi,Kobayashi, Kunihiko,Tohma, Masahiko
, p. 426 - 429 (2007/10/02)
18,20-Epoxy-11β,17α,20β,21-tetrahydroxypregn-4-en-3-one was synthesized by the application of hypoiodite reaction to the cortisol acetonide. The intermediary 18-iodo derivative was converted to the 11-oxo steroid by chromic acid prior to silver ion-assisted solvolysis. Removal of the protective group with hydrochloric acid was finally carried out to give the desired 11β,17α,18,21-tetrahydroxypregn-4-ene3,20-dione as the hemiacetal form. 18,20-Epoxy-11β-17α,20β,21-tetrahydroxypregna-1,4-dien-3-one was also prepared from prednisolone through a similar reaction sequence.
